HEMA 2: Megakaryopoiesis

Production of megakaryocytes is called _____.

Responsible for the transcription of mitosis to endomitosis.

All of the following are not true about endomitosis, except:

I. Not capable of cell division

II. Lacks telophase and cytokinesis

III. Capable of cell division

IV. Cytoplasmic maturation

I, II

I, II, IV

I, IV

II, III, IV

Demarcation system can be found in which precursor?

I. MK-1

II. MK-2

III. LD-CFU-meg

IV. CFU-meg

V. Megakaryocytes

Platelets is activated once exposed to ______.

I. Serotonin

II. Endothelial cells

III. TPO

IV. ADP

V. Collagen

The following belongs to primary hemostasis, except:

1. Platelets

2. Vasodilation

3. Blood vessels

4. Coagulation factor

Vascular response that searves as the compensating mechanism in primary hemostasis.

What protein is indispensable for platelet aggregation?

Phenomenon in which platelets form a rosette around the periphery of neutrophils.

____ of platelets are sequestered in the spleen.

Glycoprotein responsible for platelet membrane.

GP Ib/IX/V

GP IIb/IIIa

GP IIa/IIIb

GP Ib/X/IV

Glycoprotein responsible for aggregation.

GP Ib/IX/V

GP IIb/IIIa

GP IIa/IIIb

GP Ib/X/IV

Phospholipid that supplies arachidonic acid for prostaglandin.

Phospholipid that is the site for secondary hemolysis.

Phospholipid that flips to the outer surface upon activation.

Platelet structure that is responsible for the contraction of platelet.

Contributes to the discoid shape of an inactivated platelet.

Responsible for the shape change of platelets.

Responsible for the exchange of substances in and out of the platelet.

Stores calcium; control center for platelet activation.

Which of the following are not an example of alpha granules?

I. Fibrinogen

II. Factor V

III. ATP

IV. C1 esterase inhibitor

V. Pyrophosphate

VI. Serotonin

HEMA 2: Megakaryopoiesis

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