Bones Shifting

A 40 year old female with rheumatoid arthritis presents with a synovial cyst that forms in the popliteal space. What is the most likely diagnosis? X

A 5 month old boy was brought to the OPD with chief complaints of short limbs and progressive enlargement of the head, Physical Examination revealed height of less than 3rd percentile and head circumference more than 97th percentile. The head appeared large with frontal bossing, wide open anterior fontanelle with midfacial hypoplasia, depressed nasal bridge and short neck with redundant skin folds. The clinical findings are compatible with:

A 70 year old Australian man presents with pain on the left leg, Radiograph of the right leg shows bwoing of the tibia and the affected portion is enlarged sclerotic and exhibits irregular thickening of both the cortical and and cancellous bone. What is the histomorphologic finding compatible with this condition?

A benign cartilage-capped tumor attached to the underlying skeleton by a bony stalk

This is a polyostotic fibrodysplasia, asssociated with cafe au lait skin pigments and endocrine anomaly especially precocious puberty.

All of the following are true in Juvenile Idiopathic Arthritis compared to RA, EXCEPT:

Which of the following diseases is associated with desmoid tumors?

A clinical subtype of superficial fibromatosis that has irregular, nodular thickenin of palmar fascia, causing puckering and dimpling, with slowly progressive flexion contracture of the 4th and 5th fingers.

Most common soft tissue sarcoma in children and adolescent

Which of the following is true about osteoclasts:

Lethal type of Osteogenesis Imperfecta:

The clinical phenotype of this skeletal disease produces abnormal clavicles, wormian bones and supernumerary teeth. The affected molecule is a transcription factor identified as RUNX2. This disease is called:

Casser John, a 35 year old father of two, presented in the clinic with a pencil in a cup deformity that affected his peripheral and axial joints. He was diagnosed with a chronic inflammatory arthropathy. This pathology is called:

Pathognomic hallmark of gout

A 70 year old man has experienced pain in the area around the knee for the past weeks. MRI shows and infiltrative tumor that measures 4 cm wide and is located inferior to the patella. The mass is within soft tissue and bony erosion is noted at the adjacent bone. A biopsy of the mass is done; microscopically, the specimen shows sheets of large anaplastic cells with bizzare nuclei. Immunohistochemical stains for myogenin and smooth muscle actin were nonreactive. Which of the following is the most diagnosis?

The morphologic hallmarks in osteoarthritis include loose body formation, bone eburnation and osteophyte formation. In women, what do you call the osteophytes seen at the distal intraphalangeal joints?

A 17 year old with knee and elbow pain for 7 weeks was seen in the clinic. Anti CCP and RF was negative but ANA was positive. Which of the following is the most likely diagnosis?

Which of the following is TRUE of Rheumatoid arthritis?

Which of the following coordinates chondrocytes proliferation and differentiation and osteoblast proliferation?

A 40 year old woman has experienced malaise, fatigue, and joint pain for the past five months. On PE, the joint involvement is symmetric and most of the affected joints are in the hands and feet. The third digits have a "swan neck" deformity, and there is ulnar deviation of both hands. Which of the following laboratory findings is most likely to be reported in this patient?