Toxicology Quiz
By:Mohamed Mamdouh
Which of the following suspect a toxicological case
Sudden deterioration in conscious level
Sudden development of excessive vomiting
History of psychiatric problem
All of the above
When you take history of present illness (toxicological) what to look for ?
What Substance
Where Site of intoxication
Route of exposure
All of the above
Grading of coma by (Reeds or GCS), inability to concentrate, apathy, agitated, depressed, hallucinated represent which of the following examination
Skin examination
Consciousness and Mental status
Pupils
Vital Signs
Mydriasis,Miosis represent which of the following examination
Skin examination
Consciousness and Mental status
Pupils
Vital Signs
Blood pressure,Respiratory rate,pulse,Temp represent which of the following examination
Skin examination
Consciousness and Mental status
Pupils
Vital Signs
Burns, erythema, corrosives and Needle tracts represent which of the following examination
Skin examination
Consciousness and Mental status
Pupils
Vital Signs
Decreased visibility of oxyhemoglobin, detected in inner side of lips or palm of hands.
Cyanosis
Pallor
Jaundice
Erythema
Bluish discoloration of skin and mucus membrane due increased level of reduced hemoglobin > 5 gm % Detected in tongue (under surface).
Cyanosis
Pallor
Jaundice
Erythema
Yellowish discoloration of skin and mucus membrane due to increased bilirubin level > 3mg %. Detected in the sclera in the day light.
Cyanosis
Pallor
Jaundice
Erythema
Collection of integrated data provided by both vital signs and clinical examination to elicit manifestations specific to toxic agent.
Antidotes.
Decontamination
Toxidromes
Dialysis
Help in diagnosis when the agent is unknown
Antidotes
Decontamination
Toxidromes
Dialysis
Atropine,scopolamine,benztropine,trihexyphen are examples of
Opioid
Anticholinergic
Sympathomimetic
Cholinergic
Chlorphenira,doxylamine,hydroxyzine are examples of
Opioid
Anticholinergic
Antihistamines
Cholinergic
Mydriasis nonreactive to light ,dry flushed skin, and urinary retention indicate which toxidrome
Cholinergic
Opioid
Anticholinergic
Sympathomimetic
Mydriasis reactive to light,Diaphoretic skin, No Urinary retention indicate which toxidrome
Cholinergic
Opioid
Anticholinergic
Sympathomimetic
Are similar in points Both cause CNS altered, agitated , pupils dilated except reaction to light
Sympathomimetic,Opioid
Sympathomimetic,Cholinergic
Anticholinergic,Sympathomimetic
Anticholinergic,Opioid
Organic phosphorous compounds, mushromes Cholin,metacholine,carbamate are examples of
Cholinergic
Opioid
Anticholinergic
Sympathomimetic
Opium, Morphin ,Herion are examples of
Cholinergic
Opioid
Anticholinergic
Sympathomimetic
Are similar in vital signs and pupils and both Miosis (pinpoint) and no reaction to light
Sympathomimetic,Opioid
Sympathomimetic,Cholinergic
Anticholinergic,Sympathomimetic
Cholinergic,Opioid
Benzodiazepine,Anti-anxity,muscle relaxants are examples of
Anticholinergic
Sympathomimetic
Opioid
Sedative-hypnotic
Which of the following cause urinary retention
Cholinergic
Opioid
Anticholinergic
Sympathomimetic
Which of the following cause Diaphoresis
A)Sympathomimetic
B)cholinergic
C)Opioid
Both A ,B
Which of the following toxidromes do NOT cause dry to skin
Sedative-hypnotic
Anticholinergic
Sympathomimetic
Opioid
A patient with opioid has bradypnea what is the color of the skin
Cyanosis
Pallor
Jaundice
Erythema
Which of the following is Specific toxicological tests
ABG
Quantitative
CBC ,coagulation profile.
Liver, kidney function
While opening air way may be needed in Laryngeal obstruction.
Tracheostomy
Colostomy
Ileostomy
All of the above
While Stabilization Breathing o2 saturation should be
70%
80%
90%
100%
Which of the following is not a Coma Cocktail drug
Naloxone
Dextrose
Atropine
Thiamine
Organophosphates, Carbamate , Bradycardia need which of the following Antidote
Botulism antitoxin
Deferoxamine
Glucagon
Atropine
Opiates need which of the following Antidote
Naloxone
N-acetylcystiene
Hyper baric oxygen
Glucagon
Paracetamol need which of the following Antidote
Atropine
N-acetylcystiene
Botulism antitoxin
Deferoxamine
Snake envenomation need which of the following Antidote
Anti-scorpion antivenom
Polyvalent snake antivenom
Deferoxamine
Naloxone
Scorpion envenomation need which of the following Antidote
Polyvalent snake antivenom
Deferoxamine
Anti-scorpion antivenom
Naloxone
Botulism intoxication need which of the following Antidote
Naloxone
Botulism antitoxin
Deferoxamine
Hyper baric oxygen
Calcium channel blockers and Beta blockers need which of the following Antidote
Naloxone
Botulism antitoxin
Calcium gluconate
Deferoxamine
Carbon monoxide poisoning need which of the following Antidote
Naloxone
Calcium gluconate
Glucagon
Hyper baric oxygen
Acute iron poisoning need which of the following Antidote
Naloxone
Deferoxamine
Hyper baric oxygen
Glucagon
Digoxin intoxication need which of the following Antidote
Digibind
Naloxone
Deferoxamine
Glucagon
While Stabilization Circulation Bolus ......... IV fluids for correction of hypotension
4-5L
5-10L
1-2L
7-8L
Should be given early as soon as possible life saving
Decontamination
Antidotes
Elimination
Supportive Treatment
To prevent absorption according to the route of exposure and delay time
Decontamination
Antidotes
Supportive Treatment
Stabilization.
Surface decontamination uses OPC , Carbolic acid(phenol) with wash with soap & water for 15 min
Dermal
Eye
Inhalation
Mouth
Surface decontamination uses wash with running water or saline for 20 min and Ophthalmic consultation is must
Dermal
Eye
Inhalation
Mouth
Surface decontamination uses Remove to fresh air, Care of respiration
Dermal
Eye
Inhalation
Mouth
Is intended to remove as much ingested toxicant from the upper gastrointestinal
Activated charcoal
Induction of emesis:
Gastric Lavage
Whole bowel irrigation
Which of the following Gastrointestinal Decontamination procedure syrup ipecac or salty water are Contraindications
Activated charcoal
Gastric Lavage
Induction of emesis
Whole bowel irrigation
Which of the following Gastrointestinal Decontamination procedure done by By using wide bore orogastric lavage tube
Activated charcoal
Gastric Lavage
Induction of emesis
Whole bowel irrigation
All of the following are Indications for Gastric Lavage before 2 hours except
Sustained preparation as theophylline
Drugs that make concretions as salicylate
OPC
All of the above
Which of the following Gastrointestinal Decontamination procedure May given oral or through the orogastric tube
Activated charcoal
Gastric Lavage
Induction of emesis
Whole bowel irrigation
Which of the following Gastrointestinal Decontamination procedure May given single dose or multiple doses
Activated charcoal
Gastric Lavage
Induction of emesis
Whole bowel irrigation
Which of the following Gastrointestinal Decontamination procedure Available in form of tablets or powder
Activated charcoal
Gastric Lavage
Induction of emesis
Whole bowel irrigation
Gastrointestinal Decontamination procedure Claimed to be more effective than emesis or GL
Activated charcoal
Whole bowel irrigation
Diuresis
Urinary Alkalization
Which of the following toxins not absorbed by Activated Charcoal
Iron
Lithium
Heavy metals as Lead and mercury
All of the above
Activated Charcoal right dose is
5-10gm/kg every 4 h
0.5-1gm/kg every 4 h
0.5-1gm/kg every 12 h
510gm/kg every 12 h
Gastrointestinal Decontamination procedure used for Large ingestions of drugs poorly adsorbed to activated charcoal.
Activated charcoal
Gastric Lavage
Induction of emesis
Whole bowel irrigation
Enhancing excretion methods are
Multiple dose activated charcoal
Diuresis
Manipulation of urine PH
Dialysis
All of the above
It is a simple method for excretion of some poisons. Its value is increased when mixed with manipulation of urine PH.
Multiple dose activated charcoal
Diuresis
Dialysis
Gastric Lavage
Which of the following position Diuresis used in
When the kidney is the main route of excretion.
Have a small volume of distribution.
Have low protein binding.
All of the above
Diuresis uses Dextrose or mixture of glucose with normal saline.
Fluid diuresis
Osmotic diuresis
Both
None of the above
Diuresis uses Mannitol 20%
Fluid diuresis
Osmotic diuresis
Both
None of the above
Enhances elimination of weak acidic toxins which have greater ionization and better excreted at urine
Multiple dose activated charcoal
Diuresis
Urinary Alkalization
Dialysis
Urinary Alkalization method are
0.5-1gm/kg every 4 h.
NaHCO3 1-2 mEq /kg IV over 3-4h.
5-10gm/kg every 12 h.
NaHCO3 10-20 mEq /kg IV over 12h.
Allow blood to circulate in contact with a semi-permeable membrane to remove substances from the blood by concentration gradient,
Multiple dose activated charcoal
Diuresis
Urinary Alkalization
Dialysis
Dialyzable drug should be:
Small volume of distribution
Having low protein binding
Having small molecular weight
All of the above
Which of the following is NOT Dialyzable drug
Lithium
Phenobarbital
Deferoxamine
Salicylates
Supportive/ Symptomatic treatment used for Coma:
Diazepam
Care of coma
IV fluids
According to type
Supportive/ Symptomatic treatment used for Convulsion:
Diazepam
Care of coma
IV fluids, Alkalinization of urine
Antiarrhythmics
Supportive/ Symptomatic treatment used for Rhabdomyolysis:
Diazepam
Care of coma
IV fluids, Alkalinization of urine
Antiarrhythmics
Supportive/ Symptomatic treatment used for Acid base disturbance:
Diazepam
IV fluids, Alkalinization of urine
According to type
O2, mechanical ventilation
Supportive/ Symptomatic treatment used for Pulmonary edema:
Diazepam
IV fluids, Alkalinization of urine
According to type
Mechanical ventilation (PEEP)
Supportive/ Symptomatic treatment used for Respiratory failure:
Diazepam
IV fluids, Alkalinization of urine
O2, mechanical ventilation
According to type
Supportive/ Symptomatic treatment used for Shock
IV fluids, Alkalinization of urine
IV fluids, vasopressors, inotropics
O2, mechanical ventilation
Diazepam
Supportive/ Symptomatic treatment used for Arrhythmias:
Diazepam
Cooling
IV fluids, vasopressors, inotropics
Antiarrhythmics
Supportive/ Symptomatic treatment used for Hyperthermia:
Diazepam
Cooling
IV fluids, vasopressors, inotropics
Antiarrhythmics
Urinary Alkalization Is useful for
Salicylates
Phenobarbital
Poisons producing hemolysis or rhabdomyolysis.
All of the above
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