Nafcillin, Oxacillin, Methicillin, Dicloxacillin Quiz

Why are anti-staphylococcal penicillins not effective against MRSA?

MRSA does not produce penicillin binding proteins

MRSA produces penicillin binding proteins with low affinity for beta-lactam antibiotics

MRSA enzymatically converts the penicillin to a non-effective form

MRSA neutralizes the effect of the penicillin via its efflux pump

Which of the following best describes the mechanism of bacterial resistance against penicillinase-resistant penicillins acquired by methicillin-resistant Staphylococcus aureus (MRSA)?

Altered penicillin binding proteins

Expression of β-lactamase by bacterial plasmid genes

Inactivation of drug by plasmid-encoded acetyltransferase

Underexpression of bacterial catalase-peroxidase

Which of the following molecular structures makes the antibiotics nafcillin, oxacillin, methicillin, and dicloxacillin resistant to cleavage by bacterial beta-lactamases?

Beta-lactam ring

Bulky R group

Peptidyl side chain capped with a saturated alkyl tail

Sulfonyl group connected to an amine group

4 OF 5 For which of the following bacterial infections is empiric treatment with nafcillin, oxacillin, or dicloxacillin most appropriate?

Bacterial cervicitis

Bacterial meningitis

Pyelonephritis

Skin and soft tissue infections

What feature is taken by anti-staphylococcal penicillins to evade beta-lactamase?

Ability to mutate rapidly

Bulky R-groups that prevent beta-lactamase binding

Ability to bind with other proteins that neutralize beta-lactamase

Enhanced synthesis of counteracting enzymes

Nafcillin, Oxacillin, Methicillin, Dicloxacillin Quiz

More Quizzes