Grafalon

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Grafalon Knowledge Quiz

Test your understanding of Grafalon, an important immunosuppressive agent used in transplantation protocols. This quiz is designed to reinforce your knowledge and assess your grasp on various aspects of Grafalon, including its mechanisms, indications, dosing, and contraindications.

Multiple choice questions
Learn about clinical applications
Assess your knowledge about dosing and preparation

10 Questions2 MinutesCreated by AdministerRaven42

Which definition on the below describe Grafalon?

Anti Thymocyte Immunoglobuline

Anti T Leucocyte Immunoglobuline

Anti T Lymphocyte Immunoglobuline

Anti T Lymphocyte Immunoglobuline (Equine)

Anti Leucocyte Globuline

Which one of the below used for immunisation of Rabbits for Grafalon production?

Which of the following is not a mechanism of action of Grafalon?

Selective targeting of activating T Cells

Inhibition of T Cell Proliferation, TREGs induction

Blockade of Leukocyte adhesion to EC and tissue migration

T Cell depletion by CDC and by apopotosis induction

Inhibition of rejection via neurosensoral activities on Central Nervous System

Grafalon usually administered for the following indications (Select the wrong one)

Prevention of acute transplant rejection in patients receiving allogeneic SOT

Treatment of acute corticosteroid-resistant (CS-resistant) rejection after allogeneic SOT

Prevention of GvHD in adults after SCT from matched unrelated donors

Maintenance therapy to prevent chronic transplant rejection in patients receiving allogeneic SOT

Treatment of moderate and severe aplastic anaemia (only approved in a minority of countries)

Which one of the following is wrong?

Grafalon is a hypotonic concentrate that has to be diluted in sodium chloride 9 mg/ mL (0.9%) solution

A dilution ratio of 1:7 is recommended (per 1 mL Grafalon, 6 mL of sodium chloride solution should be added) to maintain the required level of osmolality

The standard infusion time in SOT is 4 hours while in SCT, 4–12-hour

A dilution ratio of 1:4 is recommended (per 1 mL Grafalon, 3 mL of sodium chloride solution should be added) to maintain the required level of osmolality

Solutions containing visible particles must not be used

What is the recommended dose of Grafalon for prevention of acute transplant rejection in patients receiving SOT?

The recommended dose range is 2 to 5 mg/kg/d Grafalon, The most common doses are in the range of 3 to 4 mg/kg/d.

The recommended dose range is 2 to 5 mg/kg/d Grafalon, The most common doses are in the range of 1 to 5 mg/kg/d.

The recommended dose range is 1 to 6 mg/kg/d Grafalon, The most common doses are in the range of 3 to 4 mg/kg/d.

The recommended dose range is 1 to 10 mg/kg/d Grafalon, The most common doses are in the range of 2 to 8 mg/kg/d.

The recommended dose is 2 mg/kg/d Grafalon

What is the recommended dose and schedule of Grafalon for Prevention of GvHD in adults after allogeneic SCT?

The recommended dose is 10 mg/kg/d Grafalon, usually starting from Day -3 to Day -1 prior to SCT.

The recommended dose is 10 mg/kg/d Grafalon, usually starting from Day -5 to Day -1 prior to SCT.

The recommended dose is 20 mg/kg/d Grafalon, usually starting from Day -3 to Day -1 prior to SCT.

The recommended dose is 20 mg/kg/d Grafalon, usually at Day -1 prior to SCT.

The recommended dose is 60 mg/kg/d Grafalon, usually starting from Day -3 to Day -1 prior to SCT.

Which are the contraindications of Grafalon?

Hypersensitivity to the active substance or to any of its excipients

Use in patients with bacterial, viral, parasitic or mycotic infections that are not under adequate therapeutic control

SOT patients with severe thrombocytopenia (i.e., <50,000 platelets/ μL), because Grafalon may enhance thrombocytopenia and thus increase the risk of haemorrhage

In patients with acute lympohoblastic leukemia

In patients with malignant tumours except in cases where SCT is performed as part of the treatment

Grafalon is an immunosupressive agent which used for..... (please choose the right answer) in SOT protocols

Which sentence(s) on the below is/are right?

There are three antibodies used for induction therapy: the lymphocyte-depleting agents, Grafalon and Thymoglobulin, and basiliximab, which is non-depleting

The addition of Grafalon induction to a standard triple or dual regimen reduces the risk of acute cellular rejection, and there is some evidence it also reduces risk of humoral rejection.

The addition of Grafalon induction to a standard triple or dual regimen reduces only the risk of acute cellular rejection

There are two antibodies used for induction therapy: the lymphocyte-depleting agents, Grafalon and Thymoglobulin

Calcineurin inhibitor (CNI) and mycophenolate mofetil (MPA) with or without corticosteroids are generally preffered for induction therapy

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