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Medo 2 - Pharmacy Committee

A visually engaging illustration of common diuretic medications, showcasing molecular structures and their effects on renal fun<wbr>ction, in a modern, clean design.

Medo 2 - Pharmacy Committee Quiz

Test your knowledge on pharmacology with our engaging quiz designed for students and professionals alike. Dive into questions covering various aspects of drug action, structure-activity relationships, and mechanisms of diuresis.

Multiple choice questions
Focus on key pharmacological concepts
Perfect for study aids and revision

12 Questions3 MinutesCreated by AnalyzingPharmacology42

The drug illustrated below : 1- Is an osmotic diuretic. 2- Is freely reabsorbed into blood stream. 3-Is selectively leads to water excretion without affecting electrolyte reabsorption. 4-Is freely filtrated through the Bowman's capsule into the renal tubule.

1 and 3

1 and 4

All except 3

Based on the SAR of carbonic anhydrase inhibitors , which of the following structural modifications is (are) mismatched with its logical explanation :

The aromatic moiety is better to be thiadiazole : to enhance the acidity of the sulfonamide

Electron withdrawal substituents at the phenyl ring :enhances drug's activity

The R1 can be oxazole :to enhance the acidity of the sulfonamide

The sulfonamide should be primary : substituents other than hydrogen decrease or abolishe activity

Replacing the sulfone moiety with a carbonyl:decrease or abolishes the acidity of the drug

Which is the following compounds best fulfills the following description :a compound that blocks the action of carbonic anhydrase and is used to treat glaucoma by reducing intraocular pressure :

B and D

Which of the following compounds is an inhibitor of the Na+\Cl- symporter and inhibits the reabsorption od sodium and chloride ions ?

A and B

Which of the following compounds is the MOST ACTIVE as a thiazide diuretic?

Which is the following structural modifications are associated with enhanced potency and\or duration of action of the following thiazide drug?

A-Replacment of the chloro at position 6 with triflouromethyl

B-Reduction of the C3-C4 double bond

C-Hydrophilic substituent at C3

D- All of the above

E- A and C

All of the following sentences regarding the shown drug are wrong , EXCEPT:

It is a thiazide diuretic

Competes with chloride ion at the Na+\Cl- symporter and inhibits the reabsorption od sodium and chloride ions

Is a phthalamide derivative

Is ineffective as a diuretic and is mainly used for treatment glaucoma

All are wrong

Examine the following two drugs and select the INCORRECT sentence from those that follow . *A is the first drug from the left, B on the right.

Both drugs are K-depleting diuretics

Drug A is a thiazide analogue

Both drugs are potent diuretics

Drug B is more potent diuretic than A

The carboxylic moiety of the drug A can be isosterically replaced with a tetrazole without loss of activity

Which of the following sentences is ( are) CORRECT regarding drugs A and B ?

A. They are indirect K-sparing diuretics of a steroid scaffold

B. Both have same binding affinity to their target receptor

C. Hydrolysis of the thioester of A results in in active metabolites

D. A and C

E. Drug B is associated with higher incidence of sexual side effects

The most active carbonic anhydrase inhibitor is :

The most active HMG-CoA reductase inhibitor is

Which of the following structural characteristics are CURRENTLY explained or described?

The two drugs are spiro compounds which refers to the alpha-beta unsaturated ketone functionality

The cyclic ester is reffered to as lactam

Substitutes at position 7 are crucial for antagonistic activity

The oxygen-containing ring in drug B is called oxide

None of them

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