L-03-01-P58 - Molecular Basis of Cancer III

Create an educational illustration showing the molecular mechanisms of cancer, including DNA, tumor suppressor genes, and cell division. Include visuals of cells undergoing various stages of mutations and apoptosis.

Molecular Basis of Cancer Quiz

Test your knowledge on the molecular mechanisms that underpin cancer development and tumor progression. This quiz covers key concepts related to tumor suppressor genes, oncogenes, and the genetic factors involved in cancer.

Multiple choice and true/false questions
Focus on tumor suppressor genes and mechanisms of cancer
Designed for students and professionals in the medical and biological sciences

10 Questions2 MinutesCreated by ExploringCell567

59. Which of the following is incorrect about tumour suppressor genes (TSG)?

A. They are present in all cells

B. TSG can prevent rapid cell division/growth by preventing rapid cell cycling

C. They are involved in the transcription of regulatory inhibitory genes such as p53

D. TSG help negatively control rapid cell division and growth

E. They do not control apoptosis related proteins

61. True or False: the loss of one copy of a tumour suppressor gene has no effect on the cell cycle progression/development of cancer.

True

False

62. Which of the following is true about retinoblastoma gene?

A. It is a rare childhood tumour that affects the neural precursor cells of the retina

B. The disease can can only be inherited

C. Only one copy of the Rb tumour suppressor needs to be lost for the disease to occur

D. Only the retina cells would have a mutant Rb gene on chromosome 13

E. None of the above

64. Which of the following is not a function of the Rb gene?

A. Prevention of transcriptional activation of a variety of genes

B. Regulation of cellular processes such as differentiation, DNA replication and apoptosis

C. Acts as a regulator for the cell cycle progression

D. None of the above

E. All of the above

66. Cancer cells are able to survive because in many cases, they have developed the molecular mechanisms to evade cell death (apoptosis). One of the common genetic errors is in the p53 mutation. In fact, 50% of all tumours show a loss of function of p53. Which of the following is incorrect relating to p53?

A. p53 can induce specific cell responses such as cell cycle arrest and apoptosis

B. It can aid with DNA repair following DNA damage

C. p53 becomes inactivated when a cell suffers from severe DNA damage

D. Defective p53 genes can cause chromosomes to become fragmented

E. None of the above

67. Mismatch repair genes (MMR) repair DNA if errors occur during DNA replication. In cancerous cells:

A. There is an increased concentration of MMR proteins

B. MMR genes stop following the “two-hit” hypothesis

C. The effectiveness and accuracy of DNA polymerase is affected

D. Both copies of MMR are mutated

E. Only the microsatellites are repaired while the rest of the DNA is damaged

68. Which of the following does not contribute to cancer?

L-03-01-P58 - Molecular Basis of Cancer III

Molecular Basis of Cancer Quiz

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