SAM LYHENG DENTISTRY Immunology part 2
The function of major histocompatibility complex is:
Degrade T4 and T8 polypeptides
Bind antibody for cytokine secretion
Bind complement for cell lysis
Bind epitope for presentation to T-cells
The following statements are true for Class II MHC molecules, EXCEPT :
Able to carry an antigen fragment
Recognized by the CD4
Presented antigen to Tc cells
Used to participate in Th function
All of the following are a part of innate immune respond, EXCEPT :
Pathways of complement activation
Natural Killer cells
T cells secrete antibody
Macrophage secrete cytokines
All of the following are function of IgG, EXCEPT :
Primary response to antigen
Opsonize bacteries
Activate complement
Cross placenta
The class of an immunoglobulin is determined by:
Class I and II MHC
The light chain
The antigen
The heavy chain
Light chains are :
Specific for each class of antibody
Complement fixation
Reactive with antigen
Have only a constant region
Each of the following statement is a characteristic of antibodies, EXCEPT:
They have four glycoprotein chains
They contain variable region
They are phagocytes
They have specific receptor for antigen
Cytokines are produced by cells of the immune system in response to various antigen, EXCEPT:
Activate cell function
Facilitate cell lysis
Opsonization antigen
Cause histamine release
The following answer is NOT true for interleukins?:
Produced by T cells
Regulation between cells
They are not in stock
Produced by antigen
Which of the following are true statements:
IgM and IgG can fix complement
IgA can fix complement
IgE lyses allergen
IgD provides immunization
An antigenic determinant is:
A fragment of Antigen
Recognized by a epitope
Molecule of antigen
Recognized by macrophage
The following statement is the basic monomeric immunoglobulin unit, EXCEPT:
Composed of glycoproptein chains
Same protein type for all antibody classes
Able to associate with J- chain to form multimers
The receptor is TCR
Class II MHC proteins are:
Recognized by the CD8 protein
Used to kill cytotoxic T-cells
Participate in T helper function
Not able to carry an epitope
The following statement are for Class I MHC proteins, EXCEPT:
Able to carry an antigen fragment
Recognized by the CD8 protein
Killed target cells by Tc cells
Participate in T helper function
Which properties do the T-cell receptor and the antibody share in common:
Both recognize antigen fragments
Both are able to fix complement
Both have constant regions
Both are polypeptide chains
The specific type of functional activity of a T-cell following antigen recognition is determined by:
Antigen receptor
MHC class II presenting the antigen fragment
Carbohydrate side chains
CD4 or CD8 can bind antigens
Antigen-antibody reactions can result in the following:
Killed antigen
Complement fixation
Virus neutralization
All answers
Variable regions of immunoglobulin are:
Able to fix complement
N-terminal of heavy chains
C-terminal of heavy chains
Specific recognition of antigen
The J-chain of immunoglobulin is :
Made only by epithelial cells
Present in IgM
Present in IgG
Made by T cells
The T-cell receptor is:
Recognized antigen fragments
Secreted by the T-cell
Recognized antibody
Bivalent
The following statement are for Target cell lysis and destruction, EXCEPT:
Cytotoxic T-cells recognizing specific epitopes on the target cell surface
Perforin released from antigen-specific cytotoxic T-cells
Complement binding to IgG and IgM which have bound to epitopes on the target cell
Complement binding to IgE which have bound to epitopes on the cell surface
The following statement is true for helper T-cells :
Helper cells recognize antigen with MHC class I
Helper cells recognize antigen with MHC class I and II
Cytotoxic cells recognize antigen with MHC class II
Helper cells recognize antigen with MHC class II
The following statement are true for Cytokines, EXCEPT:
Lymphokines are cytokines
Secreted by specialized cells
Are complement
Control and regulate the immune response
The function of cytokines are :
Bind to MHC class I
Specifically recognize antigens
Production of complement
Regulation the immune cells
All of the following are true, EXCEPT :
An epitope is a fragment of a macromolecule
The variable regions contain the antigen recognition site
An antigenic determinant is a paratope
The class of an immunoglobulin is determined by its heavy chain
The Natural Killer T Cells work in the immune system :
Adaptive immunity
Link between Adaptive and Innate immune
Innate immunity
Adaptive immunity and Innate immunity
The following bonds is responsible for linking of antibody to its chains:
Van der Waals forces
Hydrophobic forces
Hydrogen bonds
Disulfide bonds
Which of the following hepatitis viruses is RNA virus?:
Hepatitis A virus
Hepatitis E virus
Hepatitis B virus
Hepatitis G virus
The following hepatitis can be prevented by vaccination :
Hepatitis B and C
Hepatitis C and E
Hepatitis D and C
Hepatitis A and B
Which of the following immune cells are effective to destroying intracellular pathogens:
T helper cells
B cells
Antibodies
T cytolytic cells
The following activities are belong to the B-cells :
Act as antigen-processing cells
Antibodies response to antigens
Differentiate into plasma cells
Receptor antigen monovalent
Which of the following DOES NOT play a role in antigen presentation:
MHC class I molecules
MHC class II molecules
MHC class III molecules
Complement
The variable regions in the light chains participate in:
Fc receptor binding.
Epitope binding.
Affinity of the complement receptors.
Interaction of the Fab with cytokines.
Which of the following antibody fragments consists of a dimer of the heavy-chain constant region but lacks the CH1 domains?:
F(ab)’2
F(ab)'
Fab
Fc
The variable regions in the heavy chains participate in:
Antigen receptor
Complement receptor
Cellular receptor
Cytokine receptor
Immunoglobulins do which of the following?:
Antigen binding
Opsonisation
Complement fixation
All of the above
The Natural Killer Cells work in the immune system :
Adaptive immunity
Kill extracellular antigen
Innate immunity
Adaptive immunity and Innate immunity
The Cytotoxic T cells kill the cells/molecules below:
Extracellular antigen
Infected cells
Intracellular antigen
Bacteria
The following answers is receptor for complement on immunoglobulins:
Heavy chain
Fab region
Hinge region
Fc region
The function of Class III MHC proteins are :
Recognized antigen by CD4
Recognized antigen by CD8
Transport complement protein
Lyse antigen
The major function of major histocompatibility complex for antigen intracellular is:
Degrade Th and Tc
Presentation antigen to Th-cells
Bind complement for cell lysis
Presentation antigen to Tc-cells
The following statements are true for Class I MHC molecules, EXCEPT :
On the APC cells membrane
Recognized by the CD8
Tc cells kill an infected cells
Participated in Th function
The following answer is the function of IgG, EXCEPT :
Primary response to antigen
Opsonize bacteries
Activate complement
Cross placenta
The hapten carrier conjugate can activate B cells to secrete antibody :
Antigen
Immunoglobulin-Epitope
Antigenic determinant
Immunoglobulin
The following cells of immune system cam make inflammation:
Mast cells
Basophils
Monocytes
Mast cells and Basophils
The cells that have azerophilic granule to facilitate phagocytosis is:
Mast cells
Basophils
Monocytes
Neutrophils
The function of major histocompatibility complex for antigen in the cytosol is:
Transport protein
Presentation antigen to Th-cells
Bind complement for cell lysis
Presentation antigen to Tc-cells
The following statements are true for Class III MHC molecules, EXCEPT :
On the APC cells membrane
Recognized by the CD8
Tc cells kill an infected cells
Transport protein
The following answer is the function of IgM, EXCEPT :
Primary response to antigen
Opsonize bacteries
Activate complement
Cross placenta
The following molecules can activate B cells to secrete antibody, EXCEPT:
Antigen
Hapten
Antigenic determinant
Allergen
The following cells of immune system cam make IgE:
Mast cells
Eosinophils
Monocytes
Mast cells and Eosinophils
The pathway of the complement that can lyse bacteria is:
Classical pathway
Lectin pathway
Alternative pathway
Lytic pathway
The rabic vaccin is used to?:
Prevent tetanus infection
Cure tetanus infection
Prevent rabie infection
Cure rabie infection
Which of the following immune cells/molecules are most effective to destroying intracellular pthogens ?:
T helper cells
T cytotoxic cells
B cells
Plasma cells
The following diseases can be prevented by vaccination?:
Hepatitis B and C
Hepatitis C and E
Hepatitis D and C
Hepatitis A and B
Which of the following hepatitis viruses is RNA virus?:
Hepatitis B virus
Hepatitis C virus
Hepatitis D virus
Hepatitis A virus
Which of these factors can cause hepatitis?:
Viruses
Drugs and alcohol
Malfunctioning immune system
All of the above
The following characcteristic is common for T and b cells?:
Able to fix complement
Have constant regions
Recognize antigen
Polypeptide chains
Which type of cell destroys body cells that cause by infection?:
Plasma B cells
Cytotoxic T cells
Memory T cells
Memory B cells
The Live Attenuated Vaccines are used for the diseases below?:
Measles
Varicella zoster
Hepatitis A
All answers
The answer below is/are artificial active immunization?:
Killed organisms
Exposure to the infections
Attenuated organisms
Killed organisms and Attenuated organisms
The tests below show that patient is susceptible to an HBV infection?:
HBsAg negative
HBsAb negative
HBcAb negative
All answers
The tests below show that patient has an chronic infection of HBV?:
HBsAg positive
HBsAb negative
HBcAb positive
All answers
The tests below show that patient is already vaccinated against HBV?:
HBsAg negative
HBsAb positive
HBcAb negative
All answers
Which of the following require the Thymus?:
B cellsmaturation
B cel apoptosis
T cells maturation
T cells rogenitor
Which of the following technic is the best method to detect early infection of hepatitis?:
ELISA
Agglutination
RIA
PCR
The natural passive immunity are characterized by?:
Immunoglobulins
Placental transfert
Kill vaccin Immune cell
The following viral hepatitis are chronic hepatitis, EXCEPT?:
Hepatitis B
Hepatitis A
Heepatitis C
Hepatitis D
In chronic infection of hepatitis B, the antibody persists in the whole life is?:
HBsAb
HBcAb
HBcAg
HBsAg
In chronic infection of hepatitis B, the antigen persists in the whole life are?:
HBcAg
HBsAg
HBeAg
All answers
Which kind of cells worked in innate immune system and response to the tumor cells?:
T cells
B cells
NK cells
Macropages
The following cells are cells mediated immunity in adaptive immune response?:
T cells
B cells
Tc cells
All answers
The function of antibody produced by B cells are?:
Neutralisation
Opsonisation
Complement fixation
All answers
The TH cells produced cytokines to response the viral infection?:
Interferon
Tumor necrose factor
IL-2
Chimokine
These blood cells have memory after pathogens infection, EXCEPT? TH cells?:
B cells
Tc cells
Macrophages
The cancer of T cells are called?:
Non-Hodgkin lymphoma
Extranodal T cell lymphoma
Hodgkin lymphoma
All answers
The following answers are function of B cell, EXCEPT?:
Antibody secretion
APC
Complement cascade
Memory B cells
Which antigen is direct presented to B cell?:
T- Independent antigen
T- dependent antigen
Self- antigen
Non self- antigen
T cells secreted cytokine to activate T cells neighbering, This phenomen is called?:
Autocrine
Paracrine
Endocrine
None about
The vaccine prepared from living and inactivated microbe is considered as?:
A toxoid
Denatured
Antibody
Atenuated vaccin
B cells that produce large amounts of antibody are called?:
Plasma cells
Neutrophils
T cells
Memory B cells
Which of the immune cells/molecules are effective to neutralise and opsonse extracellular pathogens?:
Antibodies
Complement
T cells
B cells
The following tests show that patient got chronic infection of HCV?:
ALT elevated
Anti-HCV positive
IgM positive
ALT elevated and Anti-HCV positive
Regulatory T cells (Treg cells), formerly known as ?:
Suppressor T cells
CD4+ T reg
Adaptive T reg
Natural T reg
All of these tests show that patient has been vaccinationated against HBV, EXCEPT?:
HBsAb positive
HBsAg negative
HBcAb Negative
IgM positive
All of these tests show that patient has been infected with HBV, EXCEPT?:
HBsAb positive
HBsAg negative
HBcAb positive
HBcAg positive
The percentage of lymphocytes leave the thymus to become mature immunocompetent T cells is?:
98%
90%
2%
10%
The following disease is the cancer of lymphocyte?:
Ycobacterium
Non-Hodgkin lymphoma
Listeria
Lymphocytopenia
B cells recognised antigen presented by APC?:
Self - antigen
Nonself - antigen
T-independent antigen
T-dependent antigen
T cells secreted cytokine to activate cells in blood vessel, This phenomen is called:
Paracrine
Endocrine
Autocine
All answers
The two types of lymphocytes are ?:
T and B cells
Platelet and Erythrocyte
Erythrocyte and T cells
Platelet and B cells
Which nonspecific defense cells specialize in attacking cancer cells and virus-infected cells?:
TH cells
B cells
NK cells
Macrophages
Immunity acquired after an infection is?:
Response immunity
Innate immunity
Passive immunity
Active immunity
Which of the following virus is NOT transmitted through the parenteral route?:
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D
All of the following statements are true for the diagnosis of HBV infection, EXCEPT?:
Liver enzyme
Bilirubin
Serological HBV
Glucose test
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