SAM LYHENG DENTISTRY Immunology part 2

The function of major histocompatibility complex is:
Degrade T4 and T8 polypeptides
Bind antibody for cytokine secretion
Bind complement for cell lysis
Bind epitope for presentation to T-cells
The following statements are true for Class II MHC molecules, EXCEPT :
Able to carry an antigen fragment
Recognized by the CD4
Presented antigen to Tc cells
Used to participate in Th function
All of the following are a part of innate immune respond, EXCEPT :
Pathways of complement activation
Natural Killer cells
T cells secrete antibody
Macrophage secrete cytokines
All of the following are function of IgG, EXCEPT :
Primary response to antigen
Opsonize bacteries
Activate complement
Cross placenta
The class of an immunoglobulin is determined by:
Class I and II MHC
The light chain
The antigen
The heavy chain
Light chains are :
Specific for each class of antibody
Complement fixation
Reactive with antigen
Have only a constant region
Each of the following statement is a characteristic of antibodies, EXCEPT:
They have four glycoprotein chains
They contain variable region
They are phagocytes
They have specific receptor for antigen
Cytokines are produced by cells of the immune system in response to various antigen, EXCEPT:
Activate cell function
Facilitate cell lysis
Opsonization antigen
Cause histamine release
The following answer is NOT true for interleukins?:
Produced by T cells
Regulation between cells
They are not in stock
Produced by antigen
Which of the following are true statements:
IgM and IgG can fix complement
IgA can fix complement
IgE lyses allergen
IgD provides immunization
An antigenic determinant is:
A fragment of Antigen
Recognized by a epitope
Molecule of antigen
Recognized by macrophage
The following statement is the basic monomeric immunoglobulin unit, EXCEPT:
Composed of glycoproptein chains
Same protein type for all antibody classes
Able to associate with J- chain to form multimers
The receptor is TCR
Class II MHC proteins are:
Recognized by the CD8 protein
Used to kill cytotoxic T-cells
Participate in T helper function
Not able to carry an epitope
The following statement are for Class I MHC proteins, EXCEPT:
Able to carry an antigen fragment
Recognized by the CD8 protein
Killed target cells by Tc cells
Participate in T helper function
Which properties do the T-cell receptor and the antibody share in common:
Both recognize antigen fragments
Both are able to fix complement
Both have constant regions
Both are polypeptide chains
The specific type of functional activity of a T-cell following antigen recognition is determined by:
Antigen receptor
MHC class II presenting the antigen fragment
Carbohydrate side chains
CD4 or CD8 can bind antigens
The following statement are MOST closely related to each, EXCEPT:
Antigen
Allergen
Epitope
Antibody
The Immunoglobulins are secreted by:
Plasma cells
T-cells
B-cells
Macrophages
Antigen-antibody reactions can result in the following:
Killed antigen
Complement fixation
Virus neutralization
All answers
Variable regions of immunoglobulin are:
Able to fix complement
N-terminal of heavy chains
C-terminal of heavy chains
Specific recognition of antigen
The J-chain of immunoglobulin is :
Made only by epithelial cells
Present in IgM
Present in IgG
Made by T cells
The T-cell receptor is:
Recognized antigen fragments
Secreted by the T-cell
Recognized antibody
Bivalent
The following statement are for Target cell lysis and destruction, EXCEPT:
Cytotoxic T-cells recognizing specific epitopes on the target cell surface
Perforin released from antigen-specific cytotoxic T-cells
Complement binding to IgG and IgM which have bound to epitopes on the target cell
Complement binding to IgE which have bound to epitopes on the cell surface
The following statement is true for helper T-cells :
Helper cells recognize antigen with MHC class I
Helper cells recognize antigen with MHC class I and II
Cytotoxic cells recognize antigen with MHC class II
Helper cells recognize antigen with MHC class II
The following statement are true for Cytokines, EXCEPT:
Lymphokines are cytokines
Secreted by specialized cells
Are complement
Control and regulate the immune response
The function of cytokines are :
Bind to MHC class I
Specifically recognize antigens
Production of complement
Regulation the immune cells
All of the following are true, EXCEPT :
An epitope is a fragment of a macromolecule
The variable regions contain the antigen recognition site
An antigenic determinant is a paratope
The class of an immunoglobulin is determined by its heavy chain
The Natural Killer T Cells work in the immune system :
Adaptive immunity
Link between Adaptive and Innate immune
Innate immunity
Adaptive immunity and Innate immunity
The following bonds is responsible for linking of antibody to its chains:
Van der Waals forces
Hydrophobic forces
Hydrogen bonds
Disulfide bonds
The following organs do not affect by hepatitis virus, EXCEPT:
Heart
Liver
Brain
Kidneys
Which of the following hepatitis viruses is RNA virus?:
Hepatitis A virus
Hepatitis E virus
Hepatitis B virus
Hepatitis G virus
The following hepatitis can be prevented by vaccination :
Hepatitis B and C
Hepatitis C and E
Hepatitis D and C
Hepatitis A and B
Which of the following immune cells are effective to destroying intracellular pathogens:
T helper cells
B cells
Antibodies
T cytolytic cells
The following activities are belong to the B-cells :
Act as antigen-processing cells
Antibodies response to antigens
Differentiate into plasma cells
Receptor antigen monovalent
Which of the following DOES NOT play a role in antigen presentation:
MHC class I molecules
MHC class II molecules
MHC class III molecules
Complement
The variable regions in the light chains participate in:
Fc receptor binding.
Epitope binding.
Affinity of the complement receptors.
Interaction of the Fab with cytokines.
Which type of antibody is MOST effective in activating complement?:
IgG1
IgG2
IgG3
IgM
Which of the following antibody fragments consists of a dimer of the heavy-chain constant region but lacks the CH1 domains?:
F(ab)’2
F(ab)'
Fab
Fc
Which part of antibody lack of constant domain:
VL
CL
CL and CH
CH
The variable regions in the heavy chains participate in:
Antigen receptor
Complement receptor
Cellular receptor
Cytokine receptor
Which type of antibody is not effective in activating complement?:
IgG1
IgG2
IgG3
IgG4
Immunoglobulins do which of the following?:
Antigen binding
Opsonisation
Complement fixation
All of the above
The Natural Killer Cells work in the immune system :
Adaptive immunity
Kill extracellular antigen
Innate immunity
Adaptive immunity and Innate immunity
The Cytotoxic T cells kill the cells/molecules below:
Extracellular antigen
Infected cells
Intracellular antigen
Bacteria
The following answers is receptor for complement on immunoglobulins:
Heavy chain
Fab region
Hinge region
Fc region
The following answer is specific for antigen:
Heavy chain
Fab region
Hinge region
Fc region
The region of immunoglobulin(s) can be flexible:
Heavy chain
Fab region
Hinge region
Fc region
The following immunoglobulin(s) become monomer when they attaché antigen :
IgG
IgE
IgM
IgA
The immunoglobulin(s) that have long hinge region are/is:
IgG1
IgG2
IgG3
IgG4
The following immunoglobulin has extra domain and long tail :
IgG
IgE
IgM
IgA
These cells can be infected by Mycobacterium tuberculosis:
Macrophage
Lymphocyte
Neutrophil
Eosinophil
The function of Class III MHC proteins are :
Recognized antigen by CD4
Recognized antigen by CD8
Transport complement protein
Lyse antigen
The major function of major histocompatibility complex for antigen intracellular is:
Degrade Th and Tc
Presentation antigen to Th-cells
Bind complement for cell lysis
Presentation antigen to Tc-cells
The following statements are true for Class I MHC molecules, EXCEPT :
On the APC cells membrane
Recognized by the CD8
Tc cells kill an infected cells
Participated in Th function
The lectin pathway of the complement is initiated by:
C1qrs
Factor B
MBL
C3
The following answer is the function of IgG, EXCEPT :
Primary response to antigen
Opsonize bacteries
Activate complement
Cross placenta
The hapten carrier conjugate can activate B cells to secrete antibody :
Antigen
Immunoglobulin-Epitope
Antigenic determinant
Immunoglobulin
The following answer is Super antigen:
Virus
Mycose
Staphylococus toxin
HIV
The following cells of immune system cam make inflammation:
Mast cells
Basophils
Monocytes
Mast cells and Basophils
The cells that have azerophilic granule to facilitate phagocytosis is:
Mast cells
Basophils
Monocytes
Neutrophils
The function of major histocompatibility complex for antigen in the cytosol is:
Transport protein
Presentation antigen to Th-cells
Bind complement for cell lysis
Presentation antigen to Tc-cells
The following statements are true for Class III MHC molecules, EXCEPT :
On the APC cells membrane
Recognized by the CD8
Tc cells kill an infected cells
Transport protein
The classical pathway of the complement is initiated by:
C1qrs
Factor B
MBL
C3
The following answer is the function of IgM, EXCEPT :
Primary response to antigen
Opsonize bacteries
Activate complement
Cross placenta
The azerophilic granule used to facilitate phagocytosis:
Virus
Parasite
Mycose
Bacteria
The following molecules can activate B cells to secrete antibody, EXCEPT:
Antigen
Hapten
Antigenic determinant
Allergen
The following cells of immune system cam make IgE:
Mast cells
Eosinophils
Monocytes
Mast cells and Eosinophils
The pathway of the complement that can lyse bacteria is:
Classical pathway
Lectin pathway
Alternative pathway
Lytic pathway
The following antigen activate 25% of T cells:
Virus
Mycose
Staphylococus toxin
HIV
The factor that stabilize C3 convertase of alternative pathway is :
Factor H
Factor P
Factor I
DAF
The much potent anaphylotoxin of the complement is:
C2b
C3a
C4a
C5a
The following immunoglobulin is used to produe vaccine?:
IgG
IgM
IgA
IgG4
The rabic vaccin is used to?:
Prevent tetanus infection
Cure tetanus infection
Prevent rabie infection
Cure rabie infection
Which of the following immune cells/molecules are most effective to destroying intracellular pthogens ?:
T helper cells
T cytotoxic cells
B cells
Plasma cells
Killed Whole-Organism is used to prepare vaccines below, EXCEPT?:
Polio
Pertussis
Hepatitis B
Rabies
The following diseases can be prevented by vaccination?:
Hepatitis B and C
Hepatitis C and E
Hepatitis D and C
Hepatitis A and B
Which of the following hepatitis viruses is RNA virus?:
Hepatitis B virus
Hepatitis C virus
Hepatitis D virus
Hepatitis A virus
Which organ does hepatitis affect?:
Liver
Heart
Brain
Kidneys
Which of these factors can cause hepatitis?:
Viruses
Drugs and alcohol
Malfunctioning immune system
All of the above
The following characcteristic is common for T and b cells?:
Able to fix complement
Have constant regions
Recognize antigen
Polypeptide chains
Which type of cell destroys body cells that cause by infection?:
Plasma B cells
Cytotoxic T cells
Memory T cells
Memory B cells
The screening test for HBV infection is?:
HBcAb
HBcAg
HBsAb
HBsAg
The primairy response of antibody to the HBV is?:
IgG
IgM
IgA
IgE
The Live Attenuated Vaccines are used for the diseases below?:
Measles
Varicella zoster
Hepatitis A
All answers
The answer below is/are artificial active immunization?:
Killed organisms
Exposure to the infections
Attenuated organisms
Killed organisms and Attenuated organisms
The tests below show that patient is susceptible to an HBV infection?:
HBsAg negative
HBsAb negative
HBcAb negative
All answers
The tests below show that patient has an chronic infection of HBV?:
HBsAg positive
HBsAb negative
HBcAb positive
All answers
The tests below show that patient is already vaccinated against HBV?:
HBsAg negative
HBsAb positive
HBcAb negative
All answers
The family of hepatitis C virus is?:
Flavivirus
Hepanavirus
Ribovirus
Rotavirus
Class II MHC molecule works for?:
T helper function
Tc function
An antigen fragment
B cell activation
The chronic HCV infection develop hepatocellular carcinoma in the rate of?:
20%
5%
10%
50%
Which of the following require the Thymus?:
B cellsmaturation
B cel apoptosis
T cells maturation
T cells rogenitor
How many serotypes of HCV in the world?:
2
6
4
Many
HBV infection is characterized by the present of ?:
HBsAg
HBcAg
HBeAg
All answers
The most infection chronic and acute HBV is in?:
Adult
Children
Male
Female
The incubation period of HBV in the body is?:
30-60 days
60-100 days
45-180 days
30-90 days
The first sign of infection is the characteristic appearance of ?:
HBsAg
HBsAb
HBcAb
HBeAg
Which lymphocyte response to HBV infectin?:
Th
Tc
B cells
Macrophage
How many percentage of chronic HBV infection can lead to Cirrhosis?:
10%
15%
25%
50%
Which of the following technic is the best method to detect early infection of hepatitis?:
ELISA
Agglutination
RIA
PCR
The drug to cure post exposure of HBV is?:
IgG
IgM
IgA
IgE
When hepatitis vaccin start to use since year?:
1960
1985
199000%
2002
The natural passive immunity are characterized by?:
Immunoglobulins
Placental transfert
Kill vaccin Immune cell
The following vaccines are Live Attenuated Vaccines, EXCEPT?:
Tetanus
Polio
Varicella
Hepatitis A
The following vaccines is not used in United State?:
Polio
Varicella
Hepatitis A
Tuberculsis
The following vaccines is Microbial Fragment Vaccines?:
Clostridium tetani
Polio
Varicella
Hepatitis A
The following vaccines is used after exposure?:
Tetanus
Varicella
Hypogammaglobulinemia
TB
The following viral hepatitis are chronic hepatitis, EXCEPT?:
Hepatitis B
Hepatitis A
Heepatitis C
Hepatitis D
The following viral hepatitis is enteric hepatitis?:
Hepatitis B
Hepatitis A
Heepatitis C
Hepatitis D
The average incubation period of Hepatitis A is?:
7 days
15 days
30 days
60 days
The first immunoglobulin response to the viral hepatitis A infection is?:
IgA
IgG
IgE IgM
In chronic infection of hepatitis B, the antibody persists in the whole life is?:
HBsAb
HBcAb
HBcAg
HBsAg
In chronic infection of hepatitis B, the antigen persists in the whole life are?:
HBcAg
HBsAg
HBeAg
All answers
Which kind of cells worked in innate immune system and response to the tumor cells?:
T cells
B cells
NK cells
Macropages
Which lymphocyte are Large Granular Lymphocytes?:
T cells
B cells
NK cells
Macropages
The following cells are cells mediated immunity in adaptive immune response?:
T cells
B cells
Tc cells
All answers
The function of antibody produced by B cells are?:
Neutralisation
Opsonisation
Complement fixation
All answers
The TH cells produced cytokines to response the viral infection?:
Interferon
Tumor necrose factor
IL-2
Chimokine
These blood cells have memory after pathogens infection, EXCEPT? TH cells?:
B cells
Tc cells
Macrophages
The CD marker of B cells are?:
CD16 and CD56
CD19 and CD21
CD3 and CD8
CD3 and CD54
The cancer of T cells are called?:
Non-Hodgkin lymphoma
Extranodal T cell lymphoma
Hodgkin lymphoma
All answers
The following answers are function of B cell, EXCEPT?:
Antibody secretion
APC
Complement cascade
Memory B cells
The first antibody secreted by B cells during infection is?:
IgG
IgM
IgE IgA
Which antigen is direct presented to B cell?:
T- Independent antigen
T- dependent antigen
Self- antigen
Non self- antigen
T cells secreted cytokine to activate T cells neighbering, This phenomen is called?:
Autocrine
Paracrine
Endocrine
None about
The following immunoglobulin can opsonize antigen during acute phase infection?:
IgG
IgM
IgE IgA
The receptor BCR for an antigen on the membrane of B cell is?:
Bivalent
Monovalent
Trivalent
None about
The following answer is the best marker for Tc cells?:
CD4
CD8
CD21
CD3
These organ is primary lymphoid organ of human?:
Thymus
Spleen
Lymph node
Tonsil
The function of T cytotoxic lymphocyte is?:
Lyse paasite
Lyse pathogen
Lyse bacterie
Lyse target cell
B and T cells are produced by stem cells located in:?:
Liver
Spleen
Bone marrow
Circulatery system
The vaccine prepared from living and inactivated microbe is considered as?:
A toxoid
Denatured
Antibody
Atenuated vaccin
B cells that produce large amounts of antibody are called?:
Plasma cells
Neutrophils
T cells
Memory B cells
B Cells are activated by?:
Interferon
Memory cells
Antibody
Antigen
Cell mediated immunity in adaptive immune is carried out by?:
B cells
T cells
Antigen
Antibody
Which of the immune cells/molecules are effective to neutralise and opsonse extracellular pathogens?:
Antibodies
Complement
T cells
B cells
The first screening test to detect HBV infection is?:
HBsAb
HBsAg
HBcAb
HBcAg
The following tests show that patient got chronic infection of HCV?:
ALT elevated
Anti-HCV positive
IgM positive
ALT elevated and Anti-HCV positive
The following tests show that patient has a chronic HBV infection, EXCEPT?:
HBsAb
HBsAg
HBcAb
HBcAg
These cytokines secreted by T helper cell?:
TNF-α
Interferon
IL-2
Chimokine
T- independent antigen presented to the following lymphocyte?:
TH cells
TH1 cell
B cells
Tc cells
Regulatory T cells (Treg cells), formerly known as ?:
Suppressor T cells
CD4+ T reg
Adaptive T reg
Natural T reg
The percentage of TH cell among lymphocytes is?:
7%
19%
46%
23%
All of these tests show that patient has been vaccinationated against HBV, EXCEPT?:
HBsAb positive
HBsAg negative
HBcAb Negative
IgM positive
All of these tests show that patient has been infected with HBV, EXCEPT?:
HBsAb positive
HBsAg negative
HBcAb positive
HBcAg positive
The percentage of lymphocytes leave the thymus to become mature immunocompetent T cells is?:
98%
90%
2%
10%
The following disease is the cancer of lymphocyte?:
Ycobacterium
Non-Hodgkin lymphoma
Listeria
Lymphocytopenia
B cells recognised antigen presented by APC?:
Self - antigen
Nonself - antigen
T-independent antigen
T-dependent antigen
The first immunoglobulin secreted by B cells to make up memory cells is?:
IgM
IgA
IgD
IgG
T cells secreted cytokine to activate cells in blood vessel, This phenomen is called:
Paracrine
Endocrine
Autocine
All answers
The following receptor is for T cells?:
Scavenger receptor
Toll like receptor
TCR
BCR
The two types of lymphocytes are ?:
T and B cells
Platelet and Erythrocyte
Erythrocyte and T cells
Platelet and B cells
Lymphocytes that develop immunocompetence in the thymus are?:
B cells
T cells
NK cells
LGL's
Which nonspecific defense cells specialize in attacking cancer cells and virus-infected cells?:
TH cells
B cells
NK cells
Macrophages
Immunity acquired after an infection is?:
Response immunity
Innate immunity
Passive immunity
Active immunity
Which of the following organ is primarily infected by Hepatitis viruses?:
Intestines
Spleen
Liver
Lung
All of the following are the type RNA virus, EXCEPT?:
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis E
Which of the following virus is NOT transmitted through the parenteral route?:
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D
All of the following statements are true for the diagnosis of HBV infection, EXCEPT?:
Liver enzyme
Bilirubin
Serological HBV
Glucose test
Which of the following statements about HBV is NOT correct?:
RNA virus
Parenteral route
Can replicate
Hepato carcinoma
The tetanus vaccine is prepare from ?:
Virulence antigen
Killed antigen
Inactivated antigen
Toxin antigen
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