Target Alteration Quiz
Target Alteration Quiz
Test your knowledge on the role of various signaling pathways and genes in biological processes with our comprehensive Target Alteration Quiz. Dive into a collection of 21 thought-provoking questions designed to challenge your understanding and enhance your learning.
- Assess your comprehension of signal transduction and gene expression.
- Explore the effects of specific genes and proteins in developmental biology.
- Great for students, researchers, and anyone interested in cell signaling!
Addition of **hSlit2** up to a final **concentration** of 1 microg/ml had no detectable effect on the formation of nephrons or on branching morphogenesis of the ureteric tree after 2 or 4 days in culture, as assessed via immunofluorescence for the markers WT1 and calbindin 28K respectively.
Y
N
U
Furthermore, **expression** of **SLIT2** was restored in relatively low-expressing cell lines after treatment with 5-aza-2-deoxycytidine (5-Aza-dC).
Y
N
U
A binding ELISA experiment in mouse bone marrow-derived macrophages showed that ROBO1, rather than ROBO3, was directly associated with SLIT2, and gene silencing with Robo1 siRNA **blocked** the **SLIT2**-mediated suppression of osteoclastogenesis.
Y
N
U
**Overexpression** of orthodenticle homeobox 2 using lentivirus increased levels of known A10 elevated genes, including neuropilin 1, neuropilin 2, **slit2** and adenylyl cyclase-activating peptide in both MN9D cells and ventral mesencephalic cultures, whereas knockdown of endogenous orthodenticle homeobox 2 levels via short hairpin RNA reduced expression of these genes in ventral mesencephalic cultures.
Y
N
U
**Signal transducer and activator of transcription-6** (STAT6) inhibition **suppresses** renal cyst growth in polycystic kidney disease.
Y
N
U
**Wild-type** (WT), **Stat6** knockout (Stat6-/-), and intestinal epithelial cell-specific IL-4Rα knockout (Il-4rαΔIEC) mice were subjected to colitis-associated (AOM/DSS) and colitis-independent (sporadic) carcinogenesis.
Y
N
U
This innate collaboration was absent in IL-4(-/-) and **signal transducer and activator of transcription (STAT)-6** **(-/-)** mice and was inhibited by anti-IL-4 treatment.
Y
N
U
Disruption of the IL-4 signaling through either IL-4 neutralizing **antibody** or knockout of **signal transducer and activator of transcription (STAT)6** reversed the miR-17-92 cluster suppression in Th2 cells.
Y
N
U
To study the role of Slit in early embryos, we **overexpressed** Slit2 in the whole embryos either by injection of its mRNA into one-cell stage embryos or by heat-shock treatment of the transgenic embryos which carries the **slit2** gene under control of the heat-shock promoter.
Y
N
U
This is based on the observation that, although both Slit1 and **Slit2** are **expressed** around the ventral midline, mice defective in either gene alone exhibit few or no axon guidance defects at the optic chiasm whereas embryos lacking both Slit1 and Slit2 develop a large additional chiasm anterior to the chiasm's normal position.
Y
N
U
Identification of single-nucleotide and repeat **polymorphisms** in two candidate genes, interleukin 4 receptor (IL4RA) and **signal transducer and activator of transcription protein 6 (STAT6)**, for Th2-mediated diseases.
Y
N
U
**Inhibitory** Effect of **Slit2-N** on VEGF165-induced proliferation of vascular endothelia via Slit2-N-Robo4-Akt pathway in choroidal neovascularization.
Y
N
U
Using analysis of **knock-out** mice and in vitro assays, we found that, in the mammalian retina, Slit1 and **Slit2**, known chemorepellents for RGC axons, regulate distinct aspects of intraretinal pathfinding in different regions of the retina.
Y
N
U
Elevated temperature had no significant effect on the **level** of transcription of **these genes**.
Y
N
U
Antibody-**drug** conjugates that target **TROP2** represent a promising approach for the treatment of TROP2-expressing cancers including lung cancer and breast cancer.
Y
N
U
Our data demonstrate that Tacstd2 expression and membrane localization are tightly associated with stratified epithelial homeostasis, while **loss of** **TACSTD2** was identified in poorly differentiated SCC tissues collected from cervix, esophagus, head and neck.
Y
N
U
Soluble **human leukocyte antigen-g** and its insertion/deletion **polymorphism** in papillary thyroid carcinoma: novel potential biomarkers of disease?
Y
N
U
**Histocompatibility leukocyte antigen-G** is not **expressed** by endometriosis or endometrial tissue.
Y
N
U
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