Medchem Quizzes
Medchem Mastery Quiz
Test your knowledge of medicinal chemistry with our comprehensive quiz! This quiz contains 30 carefully crafted questions covering various aspects of drug interactions, solubility, metabolism, and more. Whether you're a student or a professional in the field, this quiz will challenge your understanding and provide valuable insights.
- 30 Multiple Choice Questions
- Instant Feedback on Answers
- Explore Key Concepts in Medicinal Chemistry
True or False: Van der waal force is more important for lipid solubility while hydrogen bonding is more important for water solubility.
True
False
Which one of the following interactions is the WEAKEST?
Hydrogen bond
Ion-dipole interaction
Van der Waal force
Covalent bond
Which one of the following molecules has the highest boiling point?
CH3CH2CH2-Cl
CH3-Cl
CH3CH2-Cl
CH3CH2CH2-Br
Which one of the following molecules contains a nitrogen atom that is sp2 hybridization?
A
B
C
D
Which one of the following structures does NOT contain an acid or base functional group that is relevant to human physiology?
A
B
C
D
Which of the following structures has the best water solubility?
A
B
C
How many hydrogen bond donor sites in the following molecule?
3
4
5
2
Which one of the following structures does NOT contain an acetal or ketal functional group?
1
2
3
Which one of the nitrogen atoms is not basic?
2
3
1
True or False: The larger the pKa, the less acidic the acid is and the less basic its conjugate base is.
True
False
Which one of the following acids has the smallest pKa?
A
B
C
D
Which one of the following molecules contain the most acidic functional group?
Aspirin
Ciprofloxacin
Ibuprofen
Valproic Acid
What is the pH of 0.1 M aqueous solution of the following compound?
6
5
5.5
4.5
Which one of the following molecules is LEAST ionized at pH = 7.4?
A
B
C
D
Which of the following phenols is the MOST ionized (charged) at pH = 7.4?
A
B
C
D
What is the major form of acetaminophen at pH = 7.4?
A
B
C
D
For albuterol, what is its major form (ionized or unionized) at pH = 1?
0%
0
0%
0
0%
0
0%
0
For ciprofloxacin (structure below), knowing that pKa(COOH) = 5.8 and pKa(amine) = 8.7, what is its major form at pH = 7.4?
0%
0
0%
0
0%
0
0%
0
The pKa for Penicillin G is 2.74. What is the percentage of its unionized form at pH = 1.74 (choose the closest value)?
10%
90%
90.91%
9.09%
Which two drug salts listed below are incompatible with each other if co-administered via IV infusion?
Decamethonium bromide vs. Calcium leucovorin
Loxepine succinate and sodium phenytoin
Albuterol sulfate and bisoprolol fumarate
Sodium naproxen and Calcium fenoprofen
Which nitrogen atom in the following molecule will be preferentially protonated first?
3
2
1
4
The pKa for naphazoline (structure below) is 10.9, what is the percentage of its ionized form at pH = 7.4?
0.1%
0.03%
99.97%
1%
For albuterol, at what pH will it be absorbed the best (assuming the same lipid membrane)?
8
1.5
7.4
6.5
For ampicillin (structure below), given its pKa(COOH) = 2.5 and pKa (-NH3+) = 8, at which compartment will it be absorbed better (assuming the same lipid membrane)?
Stomach (pH = 1)
Intestine (pH = 7)
Which of the following statement is FALSE? Correct!
LogP value determines the absorption efficiency of a drug no matter what the pH is.
The higher the pH, the better absorbed an amine drug is.
The lower the pH, the better absorbed a carboxylic acid drug is.
Which one of the following molecules is the LEAST water soluble?
C
B
A
Which statement is FALSE about LogP and LogD?
For non-ionizable drug, LogP = LogD.
LogP is pH independent, but LogD is pH dependent.
LogD measures the partition of both ionized and unionized drugs in n-octanol and water.
LogP and LogD values for the same series of drugs always follow the same trend.
Calculate the CLogP values of the following molecules using the pi values of fragments. Which one is the MOST water soluble based on these values?
Albuterol
Meclizine
Acetaminophen
Which one of the following statements on drug metabolism is FALSE? Correct!
Once a drug is metabolized, it is no longer active.
Glutathione S-transferases can detoxify some electrophilic reactive metabolites formed from bioactivation of a drug
In general, drug metabolism leads to increased water solubility, which favors excretion.
Only the drugs that survived first-pass metabolism will become bioavailable.
In the metabolism of acetaminophen, which step(s) of transformation are Phase-II metabolism?
(a), (b), and (d)
(c) only
(c) and (d) only
(a) and (b) only
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