Endocrinology 2022 N1

What is associated with Kallmann syndrome?

Monotropic Gonadotropin deficiency

Monotropic ACTH deficiency

Monotropic TSH deficiency

Monotropic Prolactin deficiency

Monotropic Growth hormone deficiency

Choose false about turner syndrome

Can also be characterized as 46 X,0 syndrome

Patients have short stature

Patients are infertile

Is associated with Cardiovascular malformations

You are an Endocrinologist and a Pregnant woman in the first trimester comes to your clinic with a TSH of 16,72 (normal 2-4), what do you do?

Measure T3 and T4 and wait for results

Do nothing, this woman does not need an Endocrinologist

Make an appointment for an USG

Initiate treatment directly

Tell her to come back in the next trimester

A patient with obesity and DM2 comes to your clinic because of suspicion of Cushing Syndrome. You do the low dose Dexamethasone suppression test and the cortisol level in the next morning is 1 μg/dl

This indicates Cushing disease

This test is not suited for Cushing syndrome diagnosis

This is an indication for iatrogenic Cushing

This test confirms Cushing syndrome

This test excludes Cushing syndrome

Which of the following is a complication of hypercortisolism?

Femoral fracture

Acute renal failure

Cachexia

Hypotension

A Man positive for Anti-TSH receptor Antibodies and very low TSH comes to your clinic. He also has Atrial fibrillation. What is the best choice of treatment?

Start with low dose Levothyroxine

Start with low dose Propylthiouracil and titrate up

Start with high dose Methimazole and high dose Beta-blocker

Start with high dose Propylthiouracil and low dose beta blocker

Start with low dose Methimazole

In which of the following can you diagnose Osteoporosis?

L1 -L2 T score = -1.4

Femoral neck T score = -2.6

Distal femur Z score = -2.4

Choose the false information about Polyglandular Autoimmune syndrome type 1 (PAS1)?

It is caused by a mutation in the Autoimmune Response Gene (AIRE) that is responsible for T cell maturation in the Thymus

It is the most common of the polyglandular syndromes

Hyperparathyroidism and candidiasis occur in childhood

Addison’s disease occurs in 60% of cases in adolescence

Symptoms of pituitary adenoma? (key)

Bilateral hemianopsia

Optic chiasm compression

Hypogonadism

Headaches

True statement of Cushing syndrome

Exogenous most commonly caused by Corticosteroid

Always caused by a tumor

True about Macroprolactinoma?

Increase the chance for pregnancy

Usually has no response to PRL stimulation test with Metoclopramide

First line treatment is surgery

Lab values in characteristic Phase of subacute viral thyroiditis?

Increased ESR, low TSH, increased T3 and T4

Elevated CRP, high TSH, slightly elevated T3 and T4

Leukopenia with lymphocytosis, low T3 and T4

Most common cause of adrenocortical insufficiency?

Metastatic cancer

Tuberculosis

C) Autoimmune adrenalitis

Hemorrhage

Lab values in secondary HYPOparathyroidism?

High PTH, Hypercalcemia, Hypophosphatemia

Low PTH, Hypercalcemia, Hyperphosphatemia

High PTH, Hypocalcemia, Hyperphosphatemia

Low PTH, Hypokalemia

21) The most common thyroid cancer in non-iodine deficiency region is:

2) What are possible complications of thyroidectomy?

Hyperparathyroidism, paralysis of vocal folds

Hypercalcemic crisis

facial nerve palsy

tetany, paralysis of vocal folds

Which imaging studies should be done in the suspicion of primary hyperparathyroidism?

) Neck ultrasound, abdominal MRI

) MRI of tibia, neck ultrasound

Scintigraphy with the Tc-99m-MIBI, abdominal MRI

Neck ultrasound, scintigraphy with Tc-99m-MIBI, DXA-absorptiometry

What is the gold standard for differentiating Cushing disease caused by a pituitary adenoma and ectopic ACTH producing cells?

Long Dexamethasone suppression test

) MRI of the pituitary

CT of the brain

Inferior petrous sinus sampling

What are the treatment options in hyperthyroidism in Graves’ disease?

methimazole, radio-iodine, gamma-knife

Methimazole, chemotherapy, operation

Ketoconazole, radio-iodine, operation

methimazole, radio-iodine, operation

Methimazole, radiation, operation

CASE: Woman, weight gain, lethargy, high TSH, low T3 and T4. What test and medication:

Anti-TSH, methimazole

Anti-TSH receptor, levothyroxine

Anti-TPO, levothyroxine

TSH, Corticosteroids

Which of the following are typical symptoms of primary adrenal insufficiency? (KEY)

Hypotension

Hyperpigmentation

Arthralgia

Nausea

FALSE about Acromegaly:

Increases risk of colon cancer

IGF1 is used for screening

Increases risk for thyroid cancer

Is treated with Dopamine Antagonists

Which of the following laboratory values is typical for primary adrenocortical insufficiency: (KEY choice)

Mark the correct statement:

Calcitonin is a marker of anaplastic thyroid cancer

Hypothyroidism we treat initially with high doses of levothyroxine, decrease stepwise at monthly intervals

Thyroid thrills and bruits may be heard in Graves’ Disease

Amiodarone treatment always causes hyperthyroidism

True about the MEN syndromes:

In MEN syndrome tumors are always functional

MEN2A is also called Wermer syndrome

N MEN1 you can observe tumors of the pituitary, prostate and parathyroid

In MEN2A Pheochromocytoma, Medullary thyroid cancer and gastrinomas are typical

In MEN2B there is no Hyperparathyroidism

37-years-old male patient reported to the emergency department complaining of paresthesia of the extremities and tongue. In physical examination you find positive Trousseau and Chvostek's signs. Which underlying disorder is the most probable cause?

Hypercalcemia due to the Hodgkin’s lymphoma

Primary hyperparathyroidism due to parathyroid adenoma

Primary hypothyroidism after thyroidectomy due to thyroid cance

Primary hypoparathyroidism after thyroidectomy due to thyroid cancer

What are the typical laboratory values in primary adrenal insufficiency

Elevated ACTH, low Cortisol, abnormal ACTH stimulation test

) Elevated ACTH, elevated Cortisol, abnormal ACTH stimulation test

Low ACTH, low Cortisol, normal ACTH stimulation test

) Low ACTH, high cortisol, abnormal ACTH stimulation test

Which of the following are characteristics of the Metabolic syndrome?

Mark the correct statement:

Radiotherapy is the first line treatment in acromegaly

A test confirming Acromegaly is OGTT when GH is not suppressed <0,4

Acromegaly is treated with Dopamine antagonists

Endocrinology 2022 N1

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