(325) Metabolic Resuscitation in Sepsis

1. Which of the following statements about thiamine is true?

A. Dogs and cats synthesize thiamine (vitamin B1) in the liver

B. Thiamine deficiency causes an accumulation of Acetyl coenzyme A

C. Thiamine (vitamin B1) is a cofactor for pyruvate dehydrogenase

D. Thiamine reduces NADPH synthesis.

2. Which of the following changes augment oxidative stress in septic patients?

A. Increased NADPH

B. Increased inducible nitric oxide synthetase

C. Increased glutathione peroxidase

D. Increased ascorbic acid

3. Which of the following statements about vitamin C is true?

A. Vitamin C increases cytokine production

B. Vitamin C deficiency is commonly diagnosed in dogs and cats in ICU

C. Vitamin C is a key enzyme for NADPH synthesis

D. Vitamin C is a cofactor for catecholamine biosynthesis

4. Which of the following statements about the synergistic effects of corticosteroids and vitamin C is true?

A. Corticosteroids reduce the oxidative effects of vitamin C

B. Corticosteroids improve the vitamin C synthesis

C. Vitamin C improves the binding of glucocorticoids to the glucocorticoid receptors

D. Vitamin C upregulates the production of endogenous glucocorticoids

5. Which of the following combination therapy has been recently investigated as HAT therapy or metabolic resuscitation therapy in human septic patients?

A. Corticosteroids, Vitamin C, Tocopherol

B. Coenzyme Q10, Vitamin C, Thiamine

C. Coenzyme Q10, Vitamin A, Tocopherol

D. Corticosteroids, Vitamin C, Thiamine

(325) Metabolic Resuscitation in Sepsis

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