MedChem: pH and pKa Qualitative Method
MedChem Quiz: Understanding pH and pKa
Test your knowledge on the relationship between pH, pKa, and drug ionization with this engaging quiz focused on medicinal chemistry. Whether you are a student or a professional, this quiz will help reinforce your understanding of how pH affects drug properties.
Key Features:
- 10 questions covering essential concepts
- Multiple choice and checkbox format for diverse learning
- Score tracking to assess your knowledge
Cefotaxime has acidic functional group (pKa = 3.4).Indicate whether it would be primarily ionized or primarily unionized at a stomach pH = 1.8
Primarily ionized
Primarily unionized
Determine what will happen to the functional group at a urinary pH = 6.1
Primarily ionized
Primarily unionized
Remain unchanged
Partially ionized
Which of the functional group on the drug will primarily unionized at a plasma pH = 7.4
0%
0
0%
0
0%
0
0%
0
What will happen if the pH = pKa?
Only acidic functional group that will ionized
The functional group will ionized 50% whether it is base or acid
The functional group will unionized 50% whether it is base or acid
Only basic functional group that will ionized
What will happen when pH > pKa?
The environment is more acidic than functional group
The acidic functional group are primarily ionized
The acidic functional group are primarily unionized
The basic functional group are primarily unionized
Why the functional group on Atenolol primarily ionized at stomach (pH = 1.8).
The environment (i.e., the pH) is more acidic than the functional group
PH < pKa
A basic functional group will be primarily ionized in an acidic environment.
A basic functional group will be primarily unionized in an acidic environment.
Choose which of the following are true?
When pH is less than pKa, the log [Base Form]/[Acid Form] will form a negative value
Acidic functional group are primarily unionized in an acidic environment
In acidic environment, proton are more available
When pH is less than pKa, the log [Base Form]/[Acid Form] will form a positive value
Drug having acidic functional group (pKa = 4.5) at gastric pH 2.1. Which of the following are true?
The log [Base Form]/[Acid Form] will form a negative value
The functional group will primarily ionized
The functional group will primarily unionized
PH > pKa
Based on the diagram above. Choose which are the following are true when the environmental pH = 8.4?
1.3 = log [Base Form]/[Acid Form]
The functional group will unionized
The environment is acidic
The functional group will ionized
Shown above is the structure of natamycin. It contains two functional group that could potentially ionized. The pKa value for natamycin are 4.6 and 8.4.Match the pKa values provided to the appropriate functional group by identify the functional group and state whether its acidic or basic.Then, determine whether it will ionized or not for each functional group at an intestinal pH = 6.2.Choose the correct answer.
Carboxylic Acid, pKa = 4.6, acidic, ionized. At an intestinal pH = 6.2, the environment (i.e., the pH) is more acidic than the functional group (i.e., the pH < pKa). A basic functional group will be primarily ionized in an acidic environment.
Primary amine, pka = 8.4, basic, unionized. At an intestinal pH = 6.2, the environment (i.e., the pH) is more acidic than the functional group (i.e., the pH < pKa). An acidic functional group will be primarily unionized in an acidic environment.
Carboxylic Acid, pKa = 4.6, acidic, unionized.At an intestinal pH = 6.2, the environment (i.e., the pH) is more acidic than the functional group (i.e., the pH < pKa). An acidic functional group will be primarily unionized in an acidic environment.
Primary amine, pka = 8.4, basic, ionized. At an intestinal pH = 6.2, the environment (i.e., the pH) is more acidic than the functional group (i.e., the pH < pKa). A basic functional group will be primarily ionized in an acidic environment.
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