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Medicinal | Lec 5-8 Assessment | 12Q

A detailed illustration of chemical structures and medicinal compounds, featuring vibrant colors and annotations highlighting various pharmacological elements.

Medicinal Chemistry Assessment

Test your knowledge and understanding of key concepts in medicinal chemistry with our comprehensive quiz focused on latest advancements and critical evaluations in the field.

This quiz includes topics such as:

Pharmacology
Drug mechanisms
Side effects and interactions
Drug design and development

12 Questions3 MinutesCreated by ThinkingMolecule42

Was developed by Bioisosteric modification

Has minimal CNS side effects

Has marked antiserotonin activity

Sa potent second generation antihistamine

The 3-phenolic OH greatly enhanced activity

It is a ureceptor antagonist and k receptor agonist

It belongs to benzomorphans

It shows hallucinogenic side effect results from its binding to a non- opioid receptor

Au+ is attached to Sulfur

Au+ is easily converted to its oxidized form

Monovalent gold

Orally bioavailable

Carboxamide NH Contributes to increasing its acidity

4-hydroxy group is not essential for activity

It is an isostere of piroxicam

Pyridyl nitrogen contributes to enolate stabilization

Is a powerful agonist at the 3 types of opioid receptors

Its mirror image has a completely different pharmacological action

It is an active metabolite of an opioid drug

Has 2 stereocenters, only R,R isomer is an opioid agonist

Ri = CH3, R2 = H, R3= heteroaryl

R1= H, R2= H, Ra= heteroaryl

Ri = CH3, R2= CH3, Ra= heteroaryl

R, = H Rz= CH3, R3= heteroaryl

Which of the following is/are true about coxibs

All of the following are correct

The sulfamoyl or sulfonyl moiety provides target selectivity

Are class of selective COX-1 inhibitors

Show Gl side effects that hindered their potential clinical usefulness

Binds to delta receptors causing hallucination

Is a weak K agonist

Is a weak µ agonist

Has powerful analgesic activity with low risk of addiction

Belongs to biologic DMARDs

Is an interleukin-1 antagonist

Stabilizes mast cells

Decreases expression of B-cells and T-cells

5-fluoro substituent improved metabolic stability

Indene ring enhanced anti-inflammatory potency

Sulfinyl group decreased side effect and increased water solubility

2-CH3 group ensures trans like conformation

Ethylene diamine derivatives

Ethanolamine ethers

Propylamine analogs

Phenothiazine Derivatives

Binds weakly to all types of opioid receptors

Cannot bind to µ receptor

Its side effect results from its binding to a non-opioid receptor

S a powerful k agonist

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