Permeability Background Quiz Part1
Permeability Background Quiz
Test your knowledge on permeability and drug absorption with our engaging quiz! This quiz covers essential topics, including drug transport mechanisms, physicochemical properties, and the principles of drug-likeness.
Participate now and enhance your understanding of:
- MDCK and Caco-2 models
- Routes of drug administration
- Lipinski's rule of 5
- Bioavailability equations
What does MDCK stand for?
Monkey Dexler Carcinoma Karyotype
Madin Darby Canine Kidney
Modulin-D- Canine Kidney
Madin-Dexler Carcinoma Kidney
Paracellular Transport describes the movement via tight junctions of cells whereas transcellular transport describes the movement across the phospholipid bilayer.
True
False
Why is the oral route of administration often desirable for clinicians? Tick all that apply.
Avoids first pass metabolism
Cost-effective
Easy to dose
Convenient for patient
Most common
Bioavailability is high as drug can enter systemic circulation easily
For a drug to cross a cell membrane via the passive, transcellular route, it must be...
Low MW only
Hydrophillic
Unionised (lipophillic)
Have a high pKa
Which of the following are physicochemcial properties which affect drug absorption?
Gut transit time
Molecular weight
Drug formulation
PKa
H bonding capacity
Presence of food
What do Lipinski's rule of 5 for "drug-likeness" state? Tick all correct answers
MW > 500 Da
Log D <5
Log P <5
< 5 H bond donors
< 15 H bonds
MW < 500 Da
Why is Caco-2 considered to be a better prediction of in vivo absorption compared to PAMPA?
Can purely assess passive permeability alone
Cheaper to run
Higher throughput
More physiologically relevant due to transporters present
What is the correct equation for bioavailability?
Fmet x dose x C0
Fgut x fabs x fhepatic x100
Fabs x 100
Fabs / Clearance
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