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10 Minute Quiz - Phar 300 - Oct 13 2020 - Dr Ruddock

A detailed illustration of molecular structures of common drugs with labels, surrounded by natural sources like willow bark and Caribbean sponge, in a scientific lab setting

Pharmaceutical Chemistry Quiz

Test your knowledge on medicinal chemistry with this engaging quiz designed for aspiring chemists and pharmaceutical professionals. Covering various topics from natural sources to drug metabolism, this quiz is an excellent way to challenge yourself and deepen your understanding.

Key features of the quiz:

11 insightful questions
Focused on key concepts in medicinal chemistry
Timed to enhance your decision-making skills

11 Questions3 MinutesCreated by CreatingMolecule729

Medicinal chemistry is concerned with small organic molecules and biologics. Which group has biologics only?

Infliximab and atorvastatin

infliximab and erythropoietin

Erythropoietin and fluticasone

Fluticasone and atorvastatin

Which century saw the beginnings of modern organic chemistry and consequently of medicinal chemistry?

17th

18th

19th

20th

Salicin is isolated from which natural source?

Chinese Ephedra

Castor plant

Aspergillus terreus

Willow bark

Cytarabine (Ara-C) and vidarabine (Ara-A), the first FDA-approved marine-derived drugs, were developed from naturally occurring nucleosides originally isolated from the Caribbean sponge Tethya crypta. Which of the following is cytarabine used to treat?

Chronic myelogenous leukemia (CML)

Herpes simplex

Severe chronic pain

Metastatic breast cancer

What are the following characteristic of the ideal drug is false?

Show favourable binding characteristics to the receptor

Equilibrium will lie to the left

The drug will be expected to dissociate from the receptor

The drug will re-enter systemic circulation

The efficacy of enalaprilic acid (I) is enhanced by altering its chemical structure to enalpril (II) Which chemical methodology is employed in the conversion of I to II?

Hydrolysis

Dimerization

Esterification

Oxidation

The first pass effect occurs in which organ of the body?

The kidneys

The liver

The gastrointestinal tract

The skin

Rapid metabolism of lidocaine led to the development of tocainide which has a half life of how many hours?

7.5h

15h

Which sequence is correct? In enterohepatic circulation ,the drug re-enters the __A_____ from the _B__ _ through the ___C____

Intestinal tract, liver, bile duct

Bile duct, Intestinal tract, liver

Liver, bile duct, Intestinal tract

Intestinal tract, bile duct, Liver

Which of following contains ONLY Phase I reactions?

Glutathionation, acetylation, sulfonation

Oxidation, acetylation, hydrolysis

Hydrolysis, Reduction, sulfonation

Oxidation, Hydrolysis, reduction

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