كويز 2 ميديسينال 2~لجنة الصيدلة

A detailed illustration of diuretics and ACE inhibitors, featuring chemical structures and molecular interactions in a scientific context.

Pharmaceutical Chemistry Quiz: Diuretics and ACE Inhibitors

Test your knowledge in medicinal chemistry with this engaging quiz that covers essential topics related to diuretics and the renin-angiotensin system. Explore the mechanisms, structures, and interactions of significant pharmaceutical compounds.

This quiz is designed for:

Pharmacy students
Medical professionals
Anyone interested in pharmacology

13 Questions3 MinutesCreated by StudyingChemistry451

The following diuretics are:

A.Inhibitors of the biosynthesis of the epithelial sodium channel

B.potent diuretics

C. Both are basic drugs

D. Usually used as a monotherapy for treating hypertension

The renin-angiotensin is responsible for maintaining cardiovascular homeostasis including blood volume, arterial blood pressure , and electrolyte balance :

True

False

The following is (are)TRUE regarding the renin-angiotensin system EXCEPT :

A.ACE ia a substrate-specific zinc-containing dipeptidyl carboxypeptidase

B. The main two anzymes are renin and angiotensin-converting enzymes(ACE)

C .it's over activity can result in hypertension and/or heart fatigue.

D.renin ia an aspartyl protease

E.none of the above

Based on your knowledge of effective ligand binding requirements to ACE, which of the following modifications of the shown structure would result in ENHANCED binding affinity?

A. Replacement of the proline amino acid with aspartic acid

B. Shrinking the ethyl linker between the terminal carboxyl (highlighted with a circle) and the amide into a methyl.

C. Adding a methyl group at the beta-position relative to the amide carbonyl.

D. Removing the amide carbonyl part.

E. Replacing the terminal carboxylic with a thiol.

Examine the structure below and select the correct sentence from those that follow:

A) It’s a dipeptide substrate analoge

B ) It’s an ACE inhibitor

C) Replacement of the a-methyl substituent with a hydroxyl group enhances binding affinity

D) A and B

Which of the following sentences regarding the ACEIs is ( are ) INCORRECT:

A) they block the formation of angeotensin 2

B ) their key interaction with the ACE binding site involves ionic interactions with a positively charged amino acid

C ) they are peptidomemetics

D) an integral functional group in all ACEIs is a Zn chelating group

E) they could be associated with dry cough as a consequence of abradykinin degradation

Examin the shown drugs below and select the correct sentence from the following.

A. Drug || is the most potent of the three

B. Drug |||is orally inactive and need to be converted into a prodrug to be absorbed

C. They all belong to the dicarboxylate group of ACELs

D. A and C

The drug illustrated below :

Examine the tow stracture below and select the INCORRECT sentence from the following

A. S-8308 has a 1-benzyl-5-acetyl-imidazol nucleus

B. The tetrazole in losartan is a bioisoster of COOH

C. The tetrazole enhance oral activity

D. Both drug are acidic

E. The metabolism stability for the carboxylic acid in S-8308 is better than that of the tetrazole

Given the general scaffold of ARBs which of the following sentences is(are) correct?

A.the imidazole is an integral part of all ARBs

B.the butyl side chain can be replace with ethyl ether without loss of activity

C.R could be either a carboxylic acid or ketone only

D. A&C

E.A&B

For the following drug, the wrong sentence concerning it is:

A.The 1,3-dithiolane fits in a hydrophobic pocket inside the active site

B. Removal of the 1,3-dithiolane will maintain activity of the compound

C. Bioactivation is essential to allow zinc coordination

D. The methyl group between the amide and secondary amine is with no effect on activity

E. It is considered a dicarboxylate ACEI<

كويز 2 ميديسينال 2~لجنة الصيدلة

Pharmaceutical Chemistry Quiz: Diuretics and ACE Inhibitors

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