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A visually engaging illustration of the human immune system highlighting antibodies, T-cells, and the complement system, with colorful diagrams and labels, scientific imagery, and a sense of complexity.

Immunology Mastery Quiz

Test your knowledge of immunology with this comprehensive quiz! Designed for students, healthcare professionals, and anyone interested in the immune system, this quiz covers a wide range of topics related to antibodies, T-cells, and the complement system.

Challenge yourself with questions about:

Antibody structure and function
Complement pathways
MHC molecules
Immunoglobulin classes
T-cell interactions

88 Questions22 MinutesCreated by LearningCell22

1. All of the following are true with respect to IgM antibodies, EXCEPT

σ� They fix complement

σ� They occur on the surface of lymphocytes

σ� They are glycoproteins

σ� They mediate allergic reaction

2. One principal function of complement is to:

Inactivate perforins

σ� Mediate the release of histamine

σ� Bind antibodies attached to cell surfaces and to lyse these cells

σ� Phagocytize antigens

3. One principal function of the Class I and Class II major histocompatibility

σ� Transduce the signal to the T-cell interior

σ� Mediate immunoglobulin class

σ� Present antigen for recognition by the T-cell receptor

σ� Stimulate production of interleukins

4. The major role of the complement system is to work in conjunction with:

σ� Antibodies to lyse cells via the C8 and C9 components

σ� MHC for cell recognition

σ� Antibodies to opsonize cells

σ� T-cell receptor for production of lymphokines

5. T-cell antigen receptors are distinguished from antibodies by which of the

σ� T-Cell receptors are glycosylated

σ� T-cell receptors must interact with antigen

σ� T-Cell receptors bind various cytokines

σ� T-Cell receptors bind complement to lyse cells

6. T-cell receptors or antibodies react with antigens

Because both are made by lymphocytes

σ� Because they have specific receptors for antigen

σ� Because both 'have light chain and heavy chain polypeptides

σ� Cause histamine release

7. All of the following are true of antigen, EXCEPT:

They are the principal immunoglobulin class involved in allergic reactions.

σ� They are involved in mediating anti-parasitic immune responses.

σ� They will cross the placenta and fix complement)

σ� They can effect the release of histamine

9. Which of the following immunoglobulins is present normally in plasma at the highest concentration?:

σ� IgG

σ� IgM

σ� IgA

σ� IgE

10. All of the following are true about antibodies, EXCEPT

σ� They fix complement.

σ� They occur on the surface of B-lymphocyte

σ� They are glycoproteins.

σ� They are a single amino acid sequence

11. In the complement system, the classic pathway initiates by the complement :

σ� C1qrs

σ� MBL

σ� C4

σ� C5

12. The immunoglobulin Joining chain (J-chain) is

σ� Produced by T-Cells

σ� Associated with IgM and IgG

σ� Associated with IgM and IgA

σ� Produced by mast cells

13. All of the following are true, EXCEPT

σ� An epitope is a portion of an antigen

σ� The variable contain the antigen recognition site

σ� IgM antibody is pentavalent

σ� IgG antibody is bivalent

14. Which immunoglobulin is the principal one found in secretions such as mucus? :

σ� IgG

σ� IgM

σ� IgA

σ� IgD

15. Individuals unable to make the C4b would be expected to have frequent infections of the

σ� Diabetis

σ� Thalassemia

σ� Liver disease

σ� Bacteria

16. The immunoglobulin class which is the least abundant in the normal adult is :

σ� IgG

σ� IgA

σ� IgD

σ� IgE

17. Class of immunoglobulins occurs :

σ� Immunizations, going from IgM to IgG

σ� Binds complement

σ� Causes the histamine release

σ� Mediates immunoglobulin class switching

18. In the alternative pathway of the complement system, the factors below are useful to prevent the generation of C3 convertase :

σ� Factor P

σ� Factor F

σ� C3-BP

σ� C1-INH

19. To stabilise the C3 convertase of the alternative pathway, the factors below are useful

σ� C3-BP

σ� Factor F

σ� Factor P

σ� C1-INH

20. The class of an immunoglobulin is determined by

σ� The variable region

σ� The J-chain

σ� The heavy chain

σ� The carbohydrate

21. Light chains are:

σ� Specific for each class of antibody

σ� Not specific for each class of antibody

σ� Reactive with antigen

σ� Have only a constant region

22. The T3 complex of the T-cell receptor :

σ� To transduce a signal to the cell's interior binding to antigen

σ� Binds complement

σ� Causes the histamine

σ� Mediates Immunoglobulin class switching

23. Which of the following is NOT true of interleukins?:

σ� They are cytokines which can be produced by various cells of the immune system.

σ� They are hormones which allow one cell to communicate with another cell.

σ� They are in need of receptors on the target cell in order to mediate their effects.

σ� They are able to bind antigen with a high level of specificity

24. The following statements are true for Immunoglobins, EXCEPT

σ� Are antibodies

σ� Five major classes : IgM, IgG, IgA, IgD, IgE

σ� All have receptors for complement

σ� Possess both variable and constant regions

25. The following statements are true for Antibodies:

σ� Are carbohydrates

σ� Are made from alpha and beta chains

σ� Contain no carbohydrate

σ� Contain heavy and light chains

26. Complement Deficiencies of C5, C6, C7, C8 and C9 can causes :

σ� Susceptibility to pyogenic bacterial infections

σ� Anaphylaxia

σ� Inability to attack the Gram-negative bacteria

σ� Lack of opsonisation

27. Class II MHC are :

σ� Recognized by the CD4 protein

σ� Used to kill by cytotoxic T-cells

σ� Used to participate in cytotoxic function

σ� Not able to carry an antigen fragment

28. The functional activity of the T-cell :

σ� Is related with CD4 or CD8 associated polypeptides

σ� Occurs after recognition of an epitope

σ� Can be mediated through cytokines

σ� Is related with CD4 or CD8 associated polypeptides, Occurs after recognition of an epitope, Can be mediated through cytokines

29. The followings statement are TRUE for Target cell lysis and destruction except

σ� Cytotoxic T-cells recognizing specific epitopes on the target cell surface

σ� Perforin released from antigen-specific cytotoxic T-cells

σ� Complement binding to IgG and IgM which have bound to epitopes on the target cell

σ� Complement binding to IgE antibodies which have bound to epitopes on the cell surface

30. The followings statement are TRUE, EXCEPT

σ� MHC Class 1 bind antigen fragments and are recognized by the Tc-cell receptor

σ� MHC Class I generally occur on all cells of the immune system

σ� MHC Class II bind antigen and are recognized by the T-cell receptor and the CD4

σ� MHC Class II carrying antigen presented to cytotoxic T cells

31. What distinguishes helper T-cells from cytotoxic T-cells

σ� Helper cells recognize antigen complexed with MHC class I molecules

σ� Cytotoxic cells recognize antigen complexed with MHC class I molecules

σ� Helper cells recognize antigen complexed with MHC class II molecules

σ� Cytotoxic cells recognize antigen complexed with MHC class I molecules and. Helper cells recognize antigen complexed with MHC class II molecules

32. Immunoglobulins are chemically

σ� Glycogens

σ� Glycoproteins

σ� Glycolipids

σ� D. Lipo-proteins

33. Superantigens presented to T cells by :

σ� APC

σ� B cell

σ� Monocyte

σ� Mast cell

34. Which of the following binds to an Fc receptor on mast cells and basophil

σ� IgA

σ� IgM

σ� IgE

σ� IgG

35. Which of the following is NOT a structural chain in class I MHC?:

σ� β1

σ� α1

σ� α2

σ� β2 –microglobin

36. Which of the following statements about leukocyte function is false?:

σ� Leukocytes are involved in the immune response.

σ� Neutrophils engulf damaged cells and pathogens by phagocytosis.

σ� Eosinophils deliver toxic granules to kill parasites. They are also involved in allergic reactions.

σ� Macrophages are phagocytic cells that are involved in the adaptive response

37. Immediate hypersensitivity reactions are below, EXCEPT:

σ� If the antigen is an allergen

σ� The consequence of antigen-antibody reactions

σ� Result from histamine release

σ� Phagocytosis

38. Clinical abnormalities of the Immune system can result from the activities below, EXCEPT:

σ� Can be facilitated by antibodies

σ� Mediated the humoral and cellular immune system

σ� Facilitated by T-cells

σ� All answers

Which of the followings are TRUE regarding an Immune response

σ� The function of the T3 complex is signal to the cell's interior after recognition the antigen

σ� The T8 serves an auxiliary role with MHC class II in cytotoxic reactions

σ� The T4 serves an auxiliary role with MHC class I in helper cell reactions

σ� The T4 secrete antibody

41. The component of immune system that can cause inflammation is

σ� Complement

σ� Immunoglobulin

σ� T lymphocytes

σ� Macrophage

42. In acute infection of Hepatitis B, the typical serologic course are:

σ� HBsAg

σ� HBcAb

σ� HBcAg

σ� HBsAb

43. The disease below can cause allergic reaction:

σ� Hepatitis

σ� Thalassemia

σ� Cancer

σ� Asthma

44. Which cells are proliferated from myeloid progenitor:

σ� B cells

σ� TH1

σ� Lymphocytes

σ� Dendritic cells

45. The function of MHC class II is:

σ� Recognized by CD4

σ� Recognized by the CD8

σ� Participated in the presentation of Ag

σ� Unable to carry antigen fragment

46. The function of Natural Killer cell is:

σ� Response to bacteria infection

σ� Damaged the target cell membrane

σ� Response to antibody

σ� Kill pathogen

47. Which cell is directly secreted immunoglobulin

σ� T lymphocyte

σ� B lymphocyte

σ� Macrophage

σ� Plasma cell

48. All of the following are true with respect to IgG antibodies, EXCEPT

σ� They fix complement

σ� They occur on the surface of B lymphocytes

σ� They are glycoproteins

σ� They mediate allergic reaction

49. One principal function of complement is not true:

σ� Activate perforins

σ� Mediate the release of histamine

σ� Lyse target cells

σ� Phagocytize antigens

50. One principal function of the Class I and Class II major histocompatibility

σ� Transduce the signal to the T-cell interior

σ� Mediate immunoglobulin class

σ� Help T cell for the recognition Antigen

σ� Stimulate production of interleukins

51. The major role of the complement C3b is to work in conjunction with

σ� Antibodies to lyse cells antgen

σ� MHC for cell recognition

σ� Antibodies to opsonize cells

σ� T-cell for production of lymphokines

52. T-cell antigen receptors (TCR) are distinguished from antibodies by which of the following:

σ� TCR are glycosylated

σ� TCR interact only with antigen :

σ� TCR bind various cytokines

σ� TCR bind complement to lyse cells

53. T-cell receptors or antibodies react with antigens

σ� Both are made by lymphocytes

σ� They have specific receptors for antigen

σ� Both have light chain and heavy chain

σ� Cause histamine release

54. All of the following are true for IgE molecules, EXCEPT:

σ� They involved in allergic reactions.

σ� They anti-parasitic immune responses.

σ� They can fix complement.

σ� They can cause the release of histamine.

55. Which of the following immunoglobulin can across placenta with the highest concentration?

σ� IgG1

σ� IgG2

σ� IgG3

σ� IgG4

56. All of the following are true about antibodies, EXCEPT

σ� They fix complement.

σ� They occur on the surface of B-lymphocyte

σ� They are glycoproteins.

σ� They are polypeptide

57. In the complement system, the lytic pathway initiated by the complement

σ� C1qrs

σ� MBL

σ� C4

σ� C5

58. All of the following are true, EXCEPT:

σ� An epitope is a portion of an antigen

σ� The variable contain the antigen recognition site

σ� IgM antibody is pentamer

σ� IgG antibody is pentavalent

59. Which immunoglobulin is the principal one that is unkown function

σ� IgG

σ� IgM

σ� IgA

σ� IgD

60. Individuals make up over C4a would be expected to have

σ� Diabetis

σ� Anaphylaxia

σ� Liver disease

σ� Bacteria

61. The immunoglobulin class which is the second abundant in the normal adult is

σ� IgG

σ� IgA :

σ� IgD

σ� IgE.

62. In the alternative pathway of the complement system, the factors below are useful to stabilise the generation of C3 convertase

σ� Factor P

σ� Factor F

σ� C3-BP

σ� C1-INH

63. The factor that dissociated the initiation of C1qrs in the classical pathway is:

σ� C3-BP

σ� Factor F

σ� Factor P

σ� C1-INH

64. The type of an immunoglobulin is determined by

σ� The variable region

σ� The light chain

σ� The heavy chain

σ� The carbohydrate

65. Each of the following is a characteristic of antibodies, EXCEPT

σ� They are proteins with variable and constant regions

σ� They contain carbohydrates

σ� They are only secreted by T-cells

σ� They combine specifically with antigen

66. The T3 complex of the T-cell receptor

σ� To transduce a signal to the cell's interior

σ� Binds complement

σ� Causes the histamine

σ� Mediates Immunoglobulin class switching

67. Which of the following is NOT true of interleukins

σ� Produced by cells of the immune system.

σ� Relation between cells of immune system

σ� They have receptors on the target cell.

σ� They bind antigen with a high specificity.

68. The following statements are true for IgE, EXCEPT

σ� They produce allergic reaction

σ� The least immunoglobulin in the plasma

σ� They bind to mast cells

σ� Can cross the placental barrier

69. IgE produce by :

σ� Mast cells

σ� B-cells

σ� T-cells

σ� Plasma cells

70. The following statements are true, EXCEPT

σ� IgM and IgG can fix complement

σ� IgA is a secretory immunoglobulin

σ� IgE mediates hypersensitivity

σ� IgD provides passive immunity

71. The following statements are true for Antibodies, EXCEPT

σ� Non immunogen

σ� Composed of variable and constant regions

σ� Made of heavy and light chains

σ� They have hypervariable region

72. The following statements are not true for Immunoglobins

σ� They have Fab

σ� Five major classes of immunoglobulin

σ� All have receptors for complement

σ� Possess both variable and constant regions

73. The following statements are true for Antibodies

σ� Are carbohydrates

σ� Are made from alpha and beta chains

σ� Contain cytoplasmic region

σ� Have variable region

σ�74. The Biological Effects of C3b is :

σ� Susceptibility to bacterial infections

σ� Anaphylaxia

σ� Phagocyte activation

σ� Lack of opsonisation

75. The following statement is for MHC Class I:

σ� Recognized by the CD8 protein

σ� Used to kill by cytotoxic T-cells

σ� Participated in helper function

σ� D. Not able to carry an antigen fragment

76. The major histocompatibility complex proteins function to

σ� Degrade T4 and T8 polypeptides

σ� Bind antibody for lymphokine production

σ� Bind complement for cell lysis

σ� Bind antigen for presentation to T-cells

77. Variable domains are:

σ� Needed to bind complement

σ� Located at the N-terminal of heavy chains

σ� Transported IgG across the placenta

σ� Specific recognition of antigen

78. The light chains of antibodies are distinguished by:

σ� Their constant specific region

σ� Their variable region domains

σ� Kappa or lambda types

σ� The J-chains that bind to them

79. Which of these cell types can play a primary role in attacking and killing cancer cells?:

σ� Platelet

σ� Cytotoxic

σ� T cell

σ� Mast cell

80. The J-chain is

σ� Made only by epithelial cells

σ� For immunoglobulin multimer formation

σ� For immunoglobulin multimer formation and Facilitates secretion of pentameric lgM

σ� Facilitates secretion of pentameric lgM

81. The functional activity of the T-cell:

σ� Is related with CD4 or CD8 associated polypeptides

σ� Occurs after recognition of an epitope

σ� Can be mediated through cytokines

σ� All answers

82. The followings statement are FALSE for Target cell lysis and destruction

σ� Tc recognizing specific epitopes

σ� Perforin released from Tc

σ� C3b fix to IgG and IgM which have epitopes

σ� C3b fix to IgE which have epitopes

83. The followings statement are TRUE, EXCEPT:

σ� MHC I bind antigen and recognized by the Tc

σ� MHC I presented on all cells of the immune

σ� MHC II bind antigen and recognized by the Th

σ� MHC II carrying antigen presented to Tc

84. What distinguishes helper T-cells from cytotoxic T-cells:

σ� Th recognize antigen with MHC I

σ� Tc recognize antigen with MHC I

σ� Th recognize antigen with MHC II

σ� Tc recognize antigen with MHC I and Th recognize antigen with MHC II

85. Clinical abnormalities of the Immune system can result from the following statement, EXCEPT

σ� Deficiency diseases

σ� Abnormal lymphocyte proliferation

σ� HIV Infection

σ� T cells proliferation

86. Which of the following represent immune system dysfunctions:

σ� Severe immunodeficiency

σ� Mast cells release histamine

σ� Facilitated by antibodies

σ� T cells proliferation

87. The following statement are for adaptive immune response, EXCEPT :

σ� Is mediated by the humoral and cellular of the immune

σ� Can be facilitated by antibodies

σ� Can be facilitated through T-cells

σ� Can be facilitated through macrophage cells

88. Which of the followings are NOT TRUE regarding an immune response

σ� The principal function of the T3 complex is signal transduction to the cell's interior

σ� The T8 serves an auxiliary role with MHC class I proteins in cytotoxic reactions

σ� The T4 serves an auxiliary role with MHC class II proteins in helper cell reactions

σ� Lymphokines are produced by T-cells in response to antigen presentation by antibody

89. Skin is a________ barrier:

σ� Anatomical

σ� Physiological

σ� Phagocytic

σ� Inflammatory

90. Which among the following is anti-bacterial ?:

σ� Interferon

σ� Lysozyme

σ� Hormone

σ� Protein

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