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A scientific illustration showing the molecular structures of Aspirin and various NSAIDs, with a focus on their effects on COX enzymes, set against a background of medical textbooks and laboratory equipment.

Aspirin and NSAIDs Quiz

Test your knowledge on the pharmacology of Aspirin and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) with this engaging quiz! Delve into the mechanisms of action, structural characteristics, and side effects of these common medications.

9 Thought-provoking questions
Multiple choice and checkbox format
Perfect for pharmacology students and professionals

9 Questions2 MinutesCreated by ExploringPharma21

Aspirin has anti-platelet (at low dose) effects compared to other NSAIDs because

It is the only NSAID that irreversibly acetylate the COX-1 active site

It is the only NSAID that reversibly blocks COX-1

It is the only NSAID that reversibly blocks COX-2

Aspirin acetylates the Ser-530 amino acid in the active site of the COX-1

True

False

Which of the following is true about the COX enzymes?

COX-1 has a wider hydrophobic “lip”

COX-2 has a wider hydrophobic “lip”

COX-1 is inducible

COX-2 inhibition causes GI side effects

Which of the following metabolites is the major culprit for the hepatotoxicity of acetaminophen (Tylenol)?

GSH

Sulfation product

N-acetyl-p-benzoquinone imine (NAPQI)

Which of the following drugs is a arylacetic acid derivative?

Naproxen

Flurbiprofen

Ibuprofen

None of the drugs

Which of the following drugs is sold as the S-enatiomer?

Naproxen

Flurbiprofen

Ibuprofen

Fenoprofen

Nabumetone presents with low incidence of GI irritation because

Prodrug doesn’t have carboxylic acid thus less irritation of stomach

Prodrug has carboxylic acid thus less irritation of stomach

Diclofenac sodium has the tendency to cause hepatotoxicity because

It is a phenylacetic acid

It is a phenylpropionic acid

It forms an electophilic quinoimine metabolite that is hepatotoxic

It forms an ester that is hepatotoxic

Which of the following is/are true about the SAR of NSAIDs. Select all that apply.

Usually a 2 carbon separating the aromatic ring and the carboxylic acid

Usually a 1 carbon separating the aromatic ring and the carboxylic acid

Anti-inflammatory effects reside in the S-(+) enantiomer

Anti-inflammatory effects reside in the R-(-) enantiomer

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